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Literature summary for 1.13.11.52 extracted from

  • Sono, M.
    The roles of superoxide anion and methylene blue in the reductive activation of indoleamine 2,3-dioxygenase by ascorbic acid or by xanthine oxidase-hypoxanthine (1989), J. Biol. Chem., 264, 1616-1622.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
methylene blue acts as electron mediator from donors to the ferric dioxygenase Oryctolagus cuniculus
additional information the enzyme can be activated through different pathways either by superoxide anion or by an electron donor-methylene blue system where the dye is acting as an electron mediator from the donor to the ferric dioxygenase Oryctolagus cuniculus
O2-
-
 Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
n-butyl isocyanide heme ligand which binds tightly to the ferrous enzyme Oryctolagus cuniculus
Superoxide dismutase 80-98% inhibition Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Oryctolagus cuniculus
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Oxidation Stability

Oxidation Stability Organism
leuco-methylene blue reduces ferric enzyme Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
small intestine
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-tryptophan + O2
-
 Oryctolagus cuniculus N-formyl-D-kynurenine
-
 ?
L-Trp + O2
-
 Oryctolagus cuniculus L-formylkynurenine
-
 ?
L-tryptophan + O2
-
 Oryctolagus cuniculus N-formyl-L-kynurenine
-
 ?