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Literature summary for 1.13.11.52 extracted from

  • Salter, M.; Hazelwood, R.; Pogson, C.I.; Iyer, R.; Madge, D.J.
    The effects of a novel and selective inhibitor of tryptophan 2,3-dioxygenase on tryptophan and serotonin metabolism in the rat (1995), Biochem. Pharmacol., 49, 1435-1442.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(E)-6-fluoro-3-[2-(3-pyridyl)vinyl]-1H-indole
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Trp + O2 Rattus norvegicus key enzyme of tryptophan catabolism, importance as regulator of whole-body tryptophan catabolism and brain levels of tryptophan and serotonin L-formylkynurenine
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Trp + O2
-
Rattus norvegicus L-formylkynurenine
-
?
L-Trp + O2 key enzyme of tryptophan catabolism, importance as regulator of whole-body tryptophan catabolism and brain levels of tryptophan and serotonin Rattus norvegicus L-formylkynurenine
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000051
-
(E)-6-fluoro-3-[2-(3-pyridyl)vinyl]-1H-indole
-
Rattus norvegicus