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Literature summary for 1.13.11.52 extracted from

  • Schimke, R.T.
    L-Tryptophan 2,3-dioxygenase (tryptophan pyrrolase) (rat liver) (1970), Methods Enzymol., 17A, 421-428.
No PubMed abstract available

General Stability

General Stability Organism
enzyme is most stable in presence of L-Trp or alpha-methyl-DL-tryptophan, and in absence of oxygen Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.4
-
D-Trp
-
Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
160000 180000 gel filtration, sucrose density gradient centrifugation Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Oxidation Stability

Oxidation Stability Organism
most stable in absence of oxygen Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.08
-
-
Rattus norvegicus

Storage Stability

Storage Stability Organism
4°C, 7-10 d, about 50% loss of activity Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Trp + O2
-
Rattus norvegicus N-formyl-D-kynurenine
-
?
L-Trp + O2 enzyme from liver is specific for Rattus norvegicus L-formylkynurenine
-
?