Literature summary for 1.13.11.52 extracted from

Mellor, A.L.; Baban, B.; Chandler, P.; Marshall, B.; Jhaver, K.; Hansen, A.; Koni, P.A.; Iwashima, M.; Munn, D.H.
Cutting edge: induced indoleamine 2,3-dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion (2003), J. Immunol., 171, 1652-1655.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-Trp + O2	Mus musculus	expression of indoleamine 2,3-dioxygenase is an inducible feature of specific subsets of dendritic cells, and provides a potential mechanistic explanation for their T cell regulatory properties	L-formylkynurenine	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
dendritic cell	the expression of the enzyme is selectively induced in specific splenic dendritic cell subsets when mice are exposed to the synthetic immunomodulatory reagent CTLA4-Ig	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Trp + O2	expression of indoleamine 2,3-dioxygenase is an inducible feature of specific subsets of dendritic cells, and provides a potential mechanistic explanation for their T cell regulatory properties	Mus musculus	L-formylkynurenine	-	?

Synonyms

Synonyms	Comment	Organism
indoleamine 2,3-dioxygenase	-	Mus musculus

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Release 2023.1 (January 2023)