Literature summary for 1.13.11.52 extracted from

Batabyal, D.; Yeh, S.R.
Human tryptophan dioxygenase: a comparison to indoleamine 2,3-dioxygenase (2007), J. Am. Chem. Soc., 129, 15690-15701.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.18	-	D-tryptophan	pH 7.0	Homo sapiens
0.19	-	L-tryptophan	pH 7.0	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-tryptophan + O2	the initial deprotonation reaction of the indole NH group in hTDO is carried out by the evolutionarily conserved distal His. stereospecificity of hTDO is determined by the efficiency of the dioxygen chemistry	Homo sapiens	N-formyl-D-kynurenine	-	?
L-tryptophan + O2	the initial deprotonation reaction of the indole NH group in hTDO is carried out by the evolutionarily conserved distal His. stereospecificity of hTDO is determined by the efficiency of the dioxygen chemistry	Homo sapiens	N-formyl-L-kynurenine	-	?

Synonyms

Synonyms	Comment	Organism
hTDO	-	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.2	-	D-tryptophan	pH 7.0	Homo sapiens
2.1	-	L-tryptophan	pH 7.0	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
heme	-	Homo sapiens

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Release 2023.1 (January 2023)