Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-Methyltryptophan | - |
Homo sapiens | |
baicalein | uncompetitive reversible potent IDO-1 inhibitor | Homo sapiens | |
Berberine | uncompetitive reversible potent IDO-1 inhibitor | Homo sapiens | |
Jatrorrhizine | irreversible potent IDO-1 inhibitor | Homo sapiens | |
additional information | the traditional Chinese medicinal prescription Oren-gedoku-to significantly inhibits recombinant human IDO-1 activity in vitro | Homo sapiens | |
palmatine | irreversible potent IDO-1 inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDO-1 | - |
Homo sapiens |
indoleamine 2, 3-dioxygenase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.008 | - |
Berberine | pH and temperature not specified in the publication | Homo sapiens | |
0.215 | - |
baicalein | pH and temperature not specified in the publication | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0093 | - |
pH and temperature not specified in the publication | Homo sapiens | Berberine |
General Information | Comment | Organism |
---|---|---|
physiological function | IDO-1 is one of the key players involved in the pathogenesis of Alzheimer's disease | Homo sapiens |