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Literature summary for 1.13.11.52 extracted from

  • Wu, W.; Nicolazzo, J.A.; Wen, L.; Chung, R.; Stankovic, R.; Bao, S.S.; Lim, C.K.; Brew, B.J.; Cullen, K.M.; Guillemin, G.J.
    Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimers disease brain (2013), PLoS ONE, 8, e59749.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.52

Cloned(Commentary)

Cloned (Comment) Organism
quantitative real-time RT PCR enzyme expression analysis Mus musculus
quantitative real-time RT PCR enzyme expression analysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
brain Alzheimer's disease brain Homo sapiens
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brain enzyme activity in triple transgenic Alzheimer's disease mice. Expression of TDO mRNA is significantly increased in the cerebellum of Alzheimer's disease mouse brain Mus musculus
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brain cortex
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 Mus musculus
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brain cortex
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 Homo sapiens
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cerebellum
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 Homo sapiens
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hippocampus
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 Mus musculus
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hippocampus expression of TDO mRNA is significantly increased in the hippocampus of Alzheimer's disease patient brain. TDO co-localizes with quinolinic acid, neurofibrillary tangles-tau and amyloid deposits in the hippocampus of Alzheimer's disease patient brain Homo sapiens
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additional information quantitative real-time RT PCR enzyme expression analysis in brain sectiions Mus musculus
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additional information quantitative real-time RT PCR enzyme expression analysis in brain sectiions Homo sapiens
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Synonyms

Synonyms Comment Organism
TDO
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 Mus musculus
TDO
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus the expression of TDO mRNA is significantly increased in the cerebellum of Alzheimer's disease mouse brain up

General Information

General Information Comment Organism
malfunction the kynurenine pathway is over-activated in Alzheimer's disease mice Mus musculus
metabolism tryptophan 2,3 dioxygenase is the key regulatory enzyme of the kynurenine pathway Mus musculus
metabolism tryptophan 2,3 dioxygenase is the key regulatory enzyme of the kynurenine pathway Homo sapiens