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Literature summary for 1.13.11.52 extracted from
- Inhibition of indoleamine 2,3-dioxygenase activity by fatty acids and prostaglandins A structure function analysis (2017), Prostaglandins Leukot. Essent. Fatty Acids, 122, 7-15 .
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | IDO-1 is a target for pharmacological inhibition in the treatment of cancer | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (10Z,13Z)-nonadecadienoic acid | 32% inhibition at 0.02 mM | Homo sapiens |  |
| (11Z,14Z)-eicosadienoic acid | 42% inhibition at 0.02 mM | Homo sapiens | |
| (11Z,14Z,17Z)-eisosatrienoic acid | 19% inhibition at 0.02 mM | Homo sapiens | |
| (12Z,15Z)-heneicosadienoic acid | 39% inhibition at 0.02 mM | Homo sapiens | |
| (13Z,16Z)-docosadienoic acid | 39% inhibition at 0.02 mM | Homo sapiens | |
| (13Z,16Z,19Z)-docosatrienoic acid | 52% inhibition at 0.02 mM | Homo sapiens | |
| (4Z,7Z,10Z,13Z,16Z)-docosapentaenoic acid | 48% inhibition at 0.02 mM | Homo sapiens | |
| (4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid | 35% inhibition at 0.02 mM | Homo sapiens | |
| (5Z,8Z)-7,7-dimethyl-5,8-eicosadienoic acid | 29% inhibition at 0.02 mM | Homo sapiens | |
| (5Z,8Z)-eicosadienoic acid | 42% inhibition at 0.02 mM | Homo sapiens | |
| (5Z,8Z,11Z)-eisosatrienoic acid | 45% inhibition at 0.02 mM | Homo sapiens | |
| (5Z,8Z,11Z,14Z)-eicosatetraenoic acid | 55% inhibition at 0.02 mM; 80% inhibition at 0.02 mM | Homo sapiens | |
| (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoic acid | 19% inhibition at 0.02 mM | Homo sapiens | |
| (7Z,10Z,13Z,16Z)-docosatetraenoic acid | 42% inhibition at 0.02 mM | Homo sapiens | |
| (8Z,11Z,14Z)-eisosatrienoic acid | 68% inhibition at 0.02 mM | Homo sapiens | |
| (9E,11Z)-octadecadienoic acid | 26% inhibition at 0.02 mM | Homo sapiens | |
| (9E,12E)-octadecadienoic acid | 23% inhibition at 0.02 mM | Homo sapiens | |
| (9Z,12Z)-octadecadienoic acid | 16% inhibition at 0.02 mM | Homo sapiens | |
| (9Z,12Z,15Z)-octadecatrienoic acid | 23% inhibition at 0.02 mM | Homo sapiens | |
| 15-deoxy-DELTA12,14-prostaglandin | - |
Homo sapiens | |
| arachidonate | - |
Homo sapiens | |
| additional information | inhibition of indoleamine 2,3-dioxygenase activity by fatty acids, eicosanoids and prostaglandins, structure-function-analysis, overview. No inhibition by (6Z,9Z,12Z)-octadecatrienoic and (6Z,9Z,12Z,15Z)-octadecatetraenoic | Homo sapiens | |
| prostaglandin (19R)-hydroxy-PGE2 | - |
Homo sapiens | |
| prostaglandin 13,14-dihydro-15-oxo-PGE2 | - |
Homo sapiens | |
| prostaglandin 15-oxo-PGE2 | - |
Homo sapiens | |
| prostaglandin 15-oxo-PGF2alpha | - |
Homo sapiens | |
| prostaglandin 20-hydroxy PGE2 | - |
Homo sapiens | |
| prostaglandin DELTA12-PGJ2 | - |
Homo sapiens | |
| prostaglandin PGA2 | - |
Homo sapiens | |
| prostaglandin PGD2 | - |
Homo sapiens | |
| prostaglandin PGD2 ethanolamide | - |
Homo sapiens | |
| prostaglandin PGE2 | - |
Homo sapiens | |
| prostaglandin PGE2 ethanolamide | - |
Homo sapiens | |
| prostaglandin PGF2beta | - |
Homo sapiens | |
| prostaglandin PGG2 | - |
Homo sapiens | |
| prostaglandin PGH2 | - |
Homo sapiens | |
| prostaglandin PGJ2 | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IDO-1 | - |
Homo sapiens |
| indoleamine 2,3-dioxygenase-1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | - |
Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0041 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGD2 | |
| 0.0042 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGJ2 | |
| 0.0044 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | 15-deoxy-DELTA12,14-prostaglandin | |
| 0.0046 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin DELTA12-PGJ2 | |
| 0.0046 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGE2 ethanolamide | |
| 0.0047 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGD2 ethanolamide | |
| 0.0049 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGA2 | |
| 0.0057 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGD2 ethanolamide | |
| 0.006 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin (19R)-hydroxy-PGE2 | |
| 0.0063 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGE2 ethanolamide | |
| 0.0067 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin 13,14-dihydro-15-oxo-PGE2 | |
| 0.0067 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGJ2 | |
| 0.0068 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin 15-oxo-PGE2 | |
| 0.0071 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGF2beta | |
| 0.0071 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin DELTA12-PGJ2 | |
| 0.0072 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGH2 | |
| 0.0074 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGD2 | |
| 0.0074 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGF2beta | |
| 0.0074 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin 20-hydroxy PGE2 | |
| 0.0076 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin 15-oxo-PGF2alpha | |
| 0.0078 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGA2 | |
| 0.009 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin 15-oxo-PGE2 | |
| 0.0092 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGG2 | |
| 0.0095 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin (19R)-hydroxy-PGE2 | |
| 0.0096 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGH2 | |
| 0.01 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGE2 | |
| 0.0112 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGG2 | |
| 0.0112 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin 20-hydroxy PGE2 | |
| 0.013 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | 15-deoxy-DELTA12,14-prostaglandin | |
| 0.0221 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGE2 | |
| 0.0231 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin 15-oxo-PGF2alpha | |
| 0.03 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin 13,14-dihydro-15-oxo-PGE2 | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | arachinoate and the prostaglandin metabolite, PGD2, repress the IFNgamma mediated activity of IDO-1 in THP-1 cells and human monocytes | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme catalyses the first and rate-limiting step in the metabolism of L-tryptophan. Degradation of L-Trp leads to the production of several immunosuppressive metabolites, including N-formyl kynurenine and kynurenine. Enzyme IDO-1 also plays a crucial role in immune suppression and tumour induced tolerance. IDO-1 acts as an inducible negative regulator of T cell viability, proliferation and activation | Homo sapiens |
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Release 2023.1 (January 2023)
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