Literature summary for 1.13.11.52 extracted from

Lin, S.Y.; Yeh, T.K.; Song, J.S.; Hung, M.S.; Cheng, M.F.; Liao, F.Y.; Li, A.S.; Cheng, S.Y.; Lin, L.M.; Chiu, C.H.; Wu, M.H.; Lin, Y.J.; Hsiao, W.; Sun, M.; Wang, Y.H.; Huang, C.H.; Tang, Y.C.; Chang, H.H.; Huang, Z.T.; Chao, Y.S.; Shih, C.; Pan, S.L.; Wu, S.Y.; Kuo, C.C.; Ueng, S.H.
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy (2018), Bioorg. Chem., 77, 600-607 .

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Inhibitors

Inhibitors	Comment	Organism
2-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoic acid	-	Homo sapiens
3-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoic acid	-	Homo sapiens
4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzamide	-	Homo sapiens
4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzene-1-sulfonamide	potent inhibitor with a moderate pharmacokinetic profile. 25% tumor growth inhibition and 30% reduction in tumor weight in a murine CT26 syngeneic model on day 18, with 100 mg/kg oral administration twice daily	Homo sapiens
4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoic acid	-	Homo sapiens
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-chlorophenyl)urea	-	Homo sapiens
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-cyanophenyl)urea	-	Homo sapiens
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-fluorophenyl)urea	-	Homo sapiens
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-methoxyphenyl)urea	-	Homo sapiens
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-methylphenyl)urea	-	Homo sapiens
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(4-chlorophenyl)urea	-	Homo sapiens
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(4-methoxyphenyl)urea	-	Homo sapiens
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(4-methylphenyl)urea	-	Homo sapiens
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-butylurea	-	Homo sapiens
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-cyclohexylurea	-	Homo sapiens
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-[3-(1H-tetrazol-5-yl)phenyl]urea	-	Homo sapiens
N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-[4-(1H-tetrazol-5-yl)phenyl]urea	-	Homo sapiens
propan-2-yl 4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoate	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tryptophan + O2	Homo sapiens	-	N-formyl-L-kynurenine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14902	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tryptophan + O2	-	Homo sapiens	N-formyl-L-kynurenine	-	?

Synonyms

Synonyms	Comment	Organism
IDO	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.0000461	-	pH and temperature not specified in the publication	Homo sapiens	N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-methoxyphenyl)urea
0.0000536	-	pH and temperature not specified in the publication	Homo sapiens	N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-methylphenyl)urea
0.0000607	-	pH and temperature not specified in the publication	Homo sapiens	N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(4-methoxyphenyl)urea
0.000065	-	pH and temperature not specified in the publication	Homo sapiens	3-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoic acid
0.0000703	-	pH and temperature not specified in the publication	Homo sapiens	N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(4-methylphenyl)urea
0.0000726	-	pH and temperature not specified in the publication	Homo sapiens	N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-[3-(1H-tetrazol-5-yl)phenyl]urea
0.0000787	-	pH and temperature not specified in the publication	Homo sapiens	2-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoic acid
0.0000836	-	pH and temperature not specified in the publication	Homo sapiens	4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoic acid
0.000146	-	pH and temperature not specified in the publication	Homo sapiens	N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-cyanophenyl)urea
0.000157	-	pH and temperature not specified in the publication	Homo sapiens	N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-butylurea
0.000161	-	pH and temperature not specified in the publication	Homo sapiens	N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-cyclohexylurea
0.000184	-	pH and temperature not specified in the publication	Homo sapiens	N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(4-chlorophenyl)urea
0.000199	-	pH and temperature not specified in the publication	Homo sapiens	4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzene-1-sulfonamide
0.0002	-	pH and temperature not specified in the publication	Homo sapiens	4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzamide
0.000203	-	pH and temperature not specified in the publication	Homo sapiens	4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzene-1-sulfonamide
0.000207	-	pH and temperature not specified in the publication	Homo sapiens	N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-[4-(1H-tetrazol-5-yl)phenyl]urea
0.00023	-	pH and temperature not specified in the publication	Homo sapiens	N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-chlorophenyl)urea
0.00048	-	pH and temperature not specified in the publication	Homo sapiens	N-[4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]-N'-(3-fluorophenyl)urea
0.001202	-	pH and temperature not specified in the publication	Homo sapiens	propan-2-yl 4-[([4-[2-(4-bromophenyl)hydrazinesulfonyl]phenyl]carbamoyl)amino]benzoate

General Information

General Information	Comment	Organism
drug target	the enzyme is an anti-cancer drug target	Homo sapiens