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Literature summary for 1.13.11.52 extracted from

  • Klar, R.; Michel, S.; Schell, M.; Hinterwimmer, L.; Zippelius, A.; Jaschinski, F.
    A highly efficient modality to block the degradation of tryptophan for cancer immunotherapy locked nucleic acid-modified antisense oligonucleotides to inhibit human indoleamine 2,3-dioxygenase 1/tryptophan 2,3-dioxygenase expression (2020), Cancer Immunol. Immunother., 69, 57-67 .
    View publication on PubMed
Search for more literature for 1.13.11.52

Inhibitors

Inhibitors Comment Organism Structure
antisense oligonucleotide A06007H +G*+A*+T*T*G*T*C*C*A*G*G*A*+G*+T*+T, (+) LNA-modified nucleotide, (*) PTO linkage Homo sapiens
antisense oligonucleotide A06008H +C*+T*+C*A*A*C*T*C*T*T*T*C*+T*+C*+G, (+) LNA-modified nucleotide, (*) PTO linkage Homo sapiens
antisense oligonucleotide A06030H +A*+G*+G*C*G*C*T*G*T*G*A*C*T*+T*+G*+T, (+) LNA-modified nucleotide, (*) PTO linkage Homo sapiens
antisense oligonucleotide A06043H +C*+C*+A*G*A*C*T*C*T*A*T*G*A*G*+A*+T*+C, (+) LNA-modified nucleotide, (*) PTO linkage Homo sapiens
antisense oligonucleotide A06044H +G*+A*+G*A*T*G*A*T*C*A*A*T*G*C*+T*+G*+A, (+) LNA-modified nucleotide, (*) PTO linkage Homo sapiens
antisense oligonucleotide A06045H +A*+G*+G*C*G*C*T*G*T*G*A*C*T*T*+G*+T*+G, (+) LNA-modified nucleotide, (*) PTO linkage Homo sapiens
antisense oligonucleotide A07006H +T*+G*+T*A*T*G*A*C*A*G*C*+C*+G*+T, (+) LNA-modified nucleotide, (*) PTO linkage Homo sapiens
antisense oligonucleotide A07058H +A*+T*+C*G*T*G*G*T*G*C*T*G*A*A*+C*+A*+A, (+) LNA-modified nucleotide, (*) PTO linkage Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P14902
-
-

Source Tissue

Source Tissue Comment Organism Textmining
EFO-21 cell
-
 Homo sapiens
-
SKOV-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
IDO1
-
 Homo sapiens
indoleamine 2,3-dioxygenase 1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000011
-
 pH and temperature not specified in the publication, cellular assay of kynurenine production Homo sapiens antisense oligonucleotide A06030H
0.000017
-
 pH and temperature not specified in the publication, cellular assay of kynurenine production Homo sapiens antisense oligonucleotide A06007H
0.000036
-
 pH and temperature not specified in the publication, cellular assay of kynurenine production Homo sapiens antisense oligonucleotide A06008H
0.000049
-
 pH and temperature not specified in the publication, cellular assay of kynurenine production Homo sapiens antisense oligonucleotide A06043H
0.000078
-
 pH and temperature not specified in the publication, cellular assay of kynurenine production Homo sapiens antisense oligonucleotide A06045H
0.000205
-
 pH and temperature not specified in the publication, cellular assay of kynurenine production Homo sapiens antisense oligonucleotide A06044H
0.000368
-
 pH and temperature not specified in the publication, cellular assay of kynurenine production Homo sapiens antisense oligonucleotide A07006H
0.000842
-
 pH and temperature not specified in the publication, cellular assay of kynurenine production Homo sapiens antisense oligonucleotide A07058H

General Information

General Information Comment Organism
drug target combined treatment of cancer cells in vitro with indoleamine 2,3-dioxygenase 1-specific antisense oligonucleotides and small molecule inhibitors can reduce the production of kynurenine by cancer cells in a synergistic manner Homo sapiens
physiological function key enzyme in degradation of tryptophan into immunosuppressive kynurenine Homo sapiens