Literature summary for 1.13.11.52 extracted from

Peng, Y.H.; Liao, F.Y.; Tseng, C.T.; Kuppusamy, R.; Li, A.S.; Chen, C.H.; Fan, Y.S.; Wang, S.Y.; Wu, M.H.; Hsueh, C.C.; Chang, J.Y.; Lee, L.C.; Shih, C.; Shia, K.S.; Yeh, T.K.; Hung, M.S.; Kuo, C.C.; Song, J.S.; Wu, S.Y.; Ueng, S.H.
Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-dioxygenase inhibitors (2020), J. Med. Chem., 63, 1642-1659 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli BL21(DE3)	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
1-(4-bromophenyl)-2-[[5-(4-chlorophenyl)[1,3]thiazolo[2,3-c]-[1,2,4]triazol-3-yl]sulfanyl]ethanone	-	Homo sapiens
1-(4-cyanophenyl)-3-(3-(cyclopropylethynyl)imidazo[2,1-b]thiazol-5-yl)thiourea	potent inhibitor. The basis for this high potency is a unique sulfur-aromatic interaction network formed by the thiourea moiety of the inhibitor with F163 and F226	Homo sapiens
3-(4-bromophenyl)imidazo[2,1-b][1,3]thiazole	-	Homo sapiens
5-(4-chlorophenyl)-3-[(2-methylpropyl)sulfanyl][1,3]thiazolo-[2,3-c][1,2,4]triazole	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14902	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Synonyms

Synonyms	Comment	Organism
IDO1	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000164	-	pH and temperature not specified in the publication	Homo sapiens	1-(4-cyanophenyl)-3-(3-(cyclopropylethynyl)imidazo[2,1-b]thiazol-5-yl)thiourea
0.000256	-	pH and temperature not specified in the publication	Homo sapiens	5-(4-chlorophenyl)-3-[(2-methylpropyl)sulfanyl][1,3]thiazolo-[2,3-c][1,2,4]triazole
0.000339	-	pH and temperature not specified in the publication	Homo sapiens	1-(4-bromophenyl)-2-[[5-(4-chlorophenyl)[1,3]thiazolo[2,3-c]-[1,2,4]triazol-3-yl]sulfanyl]ethanone
0.000379	-	pH and temperature not specified in the publication	Homo sapiens	3-(4-bromophenyl)imidazo[2,1-b][1,3]thiazole

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Release 2023.1 (January 2023)