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Literature summary for 1.13.11.58 extracted from

  • Zheng, Y.; Brash, A.R.
    Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids (2010), J. Biol. Chem., 285, 39866-39875.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
13S-HPODE
-
Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Protein Variants

Protein Variants Comment Organism
A451G the mutant reacts well with arachidonic acid even in the absence of fatty acid hydroperoxides Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
9E,11Z,14Z-20:3omega6 at pH 7.5 and 22°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ contains Fe2+ Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(9E,11Z,14Z)-icosa-9,11,14-trienoic acid + O2 good substrate Homo sapiens (9S,11Z,14Z)-9-hydroperoxyicosa-11,14-dienoic acid
-
?
AA/Lyso-PA + O2
-
Homo sapiens 15-HPETE/lyso-PA + 13-HPETE/lyso-PA + 15-HPETE/lyso-PA + 11-HPETE/lyso-PA + 5-HPETE/lyso-PA 36%, 22%, 21% and 13% yield, respectively ?
arachidonic acid + O2
-
Homo sapiens 5-HPETE + 7-HPETE + 9-HPETE 22%, 25% and 29% yield, respectively ?

Synonyms

Synonyms Comment Organism
eLOX3
-
Homo sapiens
epidermal lipoxygenase-3
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.6
-
9E,11Z,14Z-20:3omega6 at pH 7.5 and 22°C Homo sapiens