Literature summary for 1.13.11.6 extracted from

Walsh, J.L.; Todd, W.P.; Carpenter, B.K.; Schwarcz, R.
4-Halo-3-hydroxyanthranilic acids: potent competitive inhibitors of 3-hydroxy-anthranilic acid oxygenase in vitro (1991), Biochem. Pharmacol., 42, 985-990.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-Bromo-3-hydroxyanthranilic acid	competitive	Rattus norvegicus
4-Chloro-3-hydroxyanthranilic acid	competitive	Rattus norvegicus
4-Fluoro-3-hydroxyanthranilic acid	competitive	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-hydroxyanthranilate + O2	-	Rattus norvegicus	2-amino-3-carboxymuconate semialdehyde	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00003	-	4-Chloro-3-hydroxyanthranilic acid	competitive	Rattus norvegicus
0.00004	-	4-Bromo-3-hydroxyanthranilic acid	competitive	Rattus norvegicus
0.00019	-	4-Fluoro-3-hydroxyanthranilic acid	competitive	Rattus norvegicus

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Release 2023.1 (January 2023)