BRENDA - Enzyme Database show
show all sequences of 1.13.11.6

Prokaryotic homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase in the 2-nitrobenzoate degradation pathway of Pseudomonas fluorescens strain KU-7

Muraki, T.; Taki, M.; Hasegawa, Y.; Iwaki, H.; Lau, P.C.; Appl. Environ. Microbiol. 69, 1564-1572 (2003)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in Escherichia coli
Pseudomonas fluorescens
Engineering
Amino acid exchange
Commentary
Organism
H52A
inactive enzyme
Pseudomonas fluorescens
H93A
24.8% activity of the native enzyme
Pseudomonas fluorescens
H96A
inactive enzyme
Pseudomonas fluorescens
Inhibitors
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
Fe2+ chelator, 1 mM, complete inhibition
Pseudomonas fluorescens
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide methiodide
carboxyl-directed reagent, 1 mM, 26% inhibition
Pseudomonas fluorescens
2,2'-dipyridyl
Fe2+ chelator, 1 mM, complete inhibition
Pseudomonas fluorescens
Cd2+
0.1 mM, more than 99% inhibition
Pseudomonas fluorescens
Co2+
1 mM, 92% inhibition
Pseudomonas fluorescens
Cu2+
0.1 mM, complete inhibition
Pseudomonas fluorescens
diethyl dicarbonate
modifies histidine residues of catechol dioxygenases, 1 mM, 70% inhibition
Pseudomonas fluorescens
Dithionitrobenzoic acid
cysteine-directed reagent, 1 mM, complete inhibition
Pseudomonas fluorescens
EDTA
1 mM, 99% inhibition
Pseudomonas fluorescens
Fe3+
0.1 mM, 82% inhibition
Pseudomonas fluorescens
iodoacetate
cysteine-directed reagent, 1 mM, 42% inhibition
Pseudomonas fluorescens
Ni2+
1 mM, 82% inhibition
Pseudomonas fluorescens
Zn2+
0.1 mM, 99% inhibition
Pseudomonas fluorescens
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Fe2+
needed for catalytic activity
Pseudomonas fluorescens
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
21240
-
predicted from cDNA sequence
Pseudomonas fluorescens
23800
-
SDS-PAGE
Pseudomonas fluorescens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3-hydroxyanthranilate + O2
Pseudomonas fluorescens
-
2-amino-3-carboxymuconate semialdehyde
-
-
?
3-hydroxyanthranilate + O2
Pseudomonas fluorescens KU-7
-
2-amino-3-carboxymuconate semialdehyde
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Pseudomonas fluorescens
Q83V26
-
-
Pseudomonas fluorescens KU-7
Q83V26
-
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
7.9
-
3-hydroxyanthranilate as substrate, pH 6.5, 30ºC
Pseudomonas fluorescens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-hydroxyanthranilate + O2
-
649382
Pseudomonas fluorescens
2-amino-3-carboxymuconate semialdehyde
-
-
-
?
3-hydroxyanthranilate + O2
-
649382
Pseudomonas fluorescens KU-7
2-amino-3-carboxymuconate semialdehyde
-
-
-
?
additional information
no detectable activity with 3-amino-4-hydroxybenzoic acid, 4-aminoresorcinol, 2-amino-m-cresol, 4-amino-3-hydroxybenzoic acid, 3-aminosalicylic acid, 6-amino-m-cresol, 3-methylcatechol, 4-methylcatechol, 1,2,4-trihydroxybenzene, 2,3-dihydroxybenzoic acid, 4-amino-m-cresol, 5-aminosalicylic acid, gentisic acid, homogentisic acid, 2-amino-4-chlorophenol, 2-amino-p-cresol, catechol, 1,2,3-trihydroxybenzene, protocatechuic acid, hydroquinone as substrates
649382
Pseudomonas fluorescens
?
-
-
-
-
additional information
no detectable activity with 3-amino-4-hydroxybenzoic acid, 4-aminoresorcinol, 2-amino-m-cresol, 4-amino-3-hydroxybenzoic acid, 3-aminosalicylic acid, 6-amino-m-cresol, 3-methylcatechol, 4-methylcatechol, 1,2,4-trihydroxybenzene, 2,3-dihydroxybenzoic acid, 4-amino-m-cresol, 5-aminosalicylic acid, gentisic acid, homogentisic acid, 2-amino-4-chlorophenol, 2-amino-p-cresol, catechol, 1,2,3-trihydroxybenzene, protocatechuic acid, hydroquinone as substrates
649382
Pseudomonas fluorescens KU-7
?
-
-
-
-
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Escherichia coli
Pseudomonas fluorescens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
H52A
inactive enzyme
Pseudomonas fluorescens
H93A
24.8% activity of the native enzyme
Pseudomonas fluorescens
H96A
inactive enzyme
Pseudomonas fluorescens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
Fe2+ chelator, 1 mM, complete inhibition
Pseudomonas fluorescens
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide methiodide
carboxyl-directed reagent, 1 mM, 26% inhibition
Pseudomonas fluorescens
2,2'-dipyridyl
Fe2+ chelator, 1 mM, complete inhibition
Pseudomonas fluorescens
Cd2+
0.1 mM, more than 99% inhibition
Pseudomonas fluorescens
Co2+
1 mM, 92% inhibition
Pseudomonas fluorescens
Cu2+
0.1 mM, complete inhibition
Pseudomonas fluorescens
diethyl dicarbonate
modifies histidine residues of catechol dioxygenases, 1 mM, 70% inhibition
Pseudomonas fluorescens
Dithionitrobenzoic acid
cysteine-directed reagent, 1 mM, complete inhibition
Pseudomonas fluorescens
EDTA
1 mM, 99% inhibition
Pseudomonas fluorescens
Fe3+
0.1 mM, 82% inhibition
Pseudomonas fluorescens
iodoacetate
cysteine-directed reagent, 1 mM, 42% inhibition
Pseudomonas fluorescens
Ni2+
1 mM, 82% inhibition
Pseudomonas fluorescens
Zn2+
0.1 mM, 99% inhibition
Pseudomonas fluorescens
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Fe2+
needed for catalytic activity
Pseudomonas fluorescens
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
21240
-
predicted from cDNA sequence
Pseudomonas fluorescens
23800
-
SDS-PAGE
Pseudomonas fluorescens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3-hydroxyanthranilate + O2
Pseudomonas fluorescens
-
2-amino-3-carboxymuconate semialdehyde
-
-
?
3-hydroxyanthranilate + O2
Pseudomonas fluorescens KU-7
-
2-amino-3-carboxymuconate semialdehyde
-
-
?
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
7.9
-
3-hydroxyanthranilate as substrate, pH 6.5, 30ºC
Pseudomonas fluorescens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-hydroxyanthranilate + O2
-
649382
Pseudomonas fluorescens
2-amino-3-carboxymuconate semialdehyde
-
-
-
?
3-hydroxyanthranilate + O2
-
649382
Pseudomonas fluorescens KU-7
2-amino-3-carboxymuconate semialdehyde
-
-
-
?
additional information
no detectable activity with 3-amino-4-hydroxybenzoic acid, 4-aminoresorcinol, 2-amino-m-cresol, 4-amino-3-hydroxybenzoic acid, 3-aminosalicylic acid, 6-amino-m-cresol, 3-methylcatechol, 4-methylcatechol, 1,2,4-trihydroxybenzene, 2,3-dihydroxybenzoic acid, 4-amino-m-cresol, 5-aminosalicylic acid, gentisic acid, homogentisic acid, 2-amino-4-chlorophenol, 2-amino-p-cresol, catechol, 1,2,3-trihydroxybenzene, protocatechuic acid, hydroquinone as substrates
649382
Pseudomonas fluorescens
?
-
-
-
-
additional information
no detectable activity with 3-amino-4-hydroxybenzoic acid, 4-aminoresorcinol, 2-amino-m-cresol, 4-amino-3-hydroxybenzoic acid, 3-aminosalicylic acid, 6-amino-m-cresol, 3-methylcatechol, 4-methylcatechol, 1,2,4-trihydroxybenzene, 2,3-dihydroxybenzoic acid, 4-amino-m-cresol, 5-aminosalicylic acid, gentisic acid, homogentisic acid, 2-amino-4-chlorophenol, 2-amino-p-cresol, catechol, 1,2,3-trihydroxybenzene, protocatechuic acid, hydroquinone as substrates
649382
Pseudomonas fluorescens KU-7
?
-
-
-
-
Other publictions for EC 1.13.11.6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741516
Pidugu
Crystal structures of human 3 ...
Homo sapiens
Acta Crystallogr. Sect. D
73
340-348
2017
-
2
1
1
-
-
1
-
-
2
-
1
-
2
-
-
1
1
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1
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2
1
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1
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1
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2
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1
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-
1
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-
-
1
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
743276
Brkic
Human 3-hydroxyanthranilate 3 ...
Homo sapiens
Mol. Biosyst.
11
898-907
2015
-
1
-
-
3
-
-
-
-
1
-
1
-
2
-
-
-
-
-
-
-
-
1
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1
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3
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1
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1
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-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
723950
Chakraborty
Aromatic ring cleavage of 2-am ...
Pseudomonas pseudoalcaligenes
Angew. Chem. Int. Ed. Engl.
52
920-924
2013
-
-
-
-
-
-
-
-
-
1
-
1
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1
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1
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-
1
-
-
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-
-
-
-
-
-
-
3
3
-
-
-
696784
Dilovic
Crystal structure of bovine 3- ...
Bos taurus
Biopolymers
91
1189-1195
2009
-
-
-
1
-
-
-
-
-
-
1
1
-
4
-
-
1
-
-
2
-
-
1
1
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1
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1
1
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1
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675557
Yates Jennifer
4-chloro-3-hydroxyanthranilate ...
Cavia porcellus, Cavia porcellus Hartley
J. Neurotrauma
23
866-881
2006
-
-
-
-
-
-
1
-
-
-
-
-
-
11
-
-
-
-
-
-
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675782
Maharaj
Acetylsalicylic acid and aceta ...
Rattus norvegicus, Rattus norvegicus Wistar
Metab. Brain Dis.
21
189-199
2006
-
-
-
-
-
-
2
-
-
-
-
-
-
171
-
-
-
-
-
1
-
-
2
-
-
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-
-
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2
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1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677020
Li
Crystal structure of 3-hydroxy ...
Saccharomyces cerevisiae
Protein Sci.
15
761-773
2006
-
-
1
1
-
-
-
-
-
2
-
1
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
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-
1
1
1
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2
-
1
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1
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-
-
1
-
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-
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672036
Colabroy
The mechanism of inactivation ...
Cupriavidus metallidurans
Biochemistry
44
7623-7631
2005
-
-
-
-
-
-
1
-
-
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1
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1
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1
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1
-
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-
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-
672037
Zhang
Structural studies on 3-hydrox ...
Cupriavidus metallidurans
Biochemistry
44
7632-7643
2005
-
-
-
1
3
-
1
4
-
1
-
-
-
1
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1
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1
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4
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1
3
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1
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4
-
1
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1
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-
-
1
-
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-
4
-
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-
-
-
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-
-
-
-
673130
Comai
The effect of age on the enzym ...
Rattus norvegicus
Clin. Chim. Acta
360
67-80
2005
-
-
-
-
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2
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-
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-
649382
Muraki
Prokaryotic homologs of the eu ...
Pseudomonas fluorescens, Pseudomonas fluorescens KU-7
Appl. Environ. Microbiol.
69
1564-1572
2003
-
-
1
-
3
-
13
-
-
1
2
2
-
5
-
-
-
-
-
-
1
-
4
-
-
-
-
-
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1
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-
3
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13
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1
2
2
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1
-
4
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658927
Nandi
Purification and inactivation ...
Bos taurus
Int. J. Biochem. Cell Biol.
35
1085-1097
2003
-
-
-
-
-
-
3
2
-
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4
1
-
2
-
-
1
-
-
2
1
-
2
1
-
-
1
-
1
-
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-
5
2
-
-
-
-
-
-
-
-
-
3
5
2
-
-
4
1
-
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1
-
2
1
-
2
1
-
-
1
-
1
-
-
2
-
-
-
-
-
-
439377
Calderone
Cloning of human 3-hydroxyanth ...
Homo sapiens
Biochim. Biophys. Acta
1596
283-292
2002
-
-
1
-
-
-
3
-
1
1
1
1
-
3
-
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1
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2
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1
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1
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3
-
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1
1
1
1
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-
-
2
-
-
-
-
1
-
-
-
-
-
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-
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439378
Agrawal
QSAR study on inhibition of br ...
Rattus norvegicus
Bioorg. Med. Chem.
9
3295-3299
2001
-
-
-
-
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-
1
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2
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1
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1
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439373
Fornstedt-Wallin
3-Hydroxyanthranilic acid accu ...
Rattus norvegicus
Eur. J. Pharmacol.
386
15-24
1999
-
-
-
-
-
-
1
-
-
-
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1
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3
-
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1
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1
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3
-
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1
-
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439376
Chiarugi
Effects of mitochondria and o- ...
Mus musculus
J. Neurochem.
72
1125-1132
1999
-
-
-
-
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-
1
-
1
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1
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1
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1
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1
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1
1
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1
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1
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1
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1
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1
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1
1
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-
439379
Kucharczyk
The yeast gene YJR025c encodes ...
Escherichia coli, Saccharomyces cerevisiae
FEBS Lett.
424
127-130
1998
-
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2
-
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2
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4
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2
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2
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