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Literature summary for 1.13.11.77 extracted from

  • Mashhadi, Z.; Boeglin, W.E.; Brash, A.R.
    Robust inhibitory effects of conjugated linolenic acids on a cyclooxygenase-related linoleate 10S-dioxygenase Comparison with COX-1 and COX-2 (2015), Biochim. Biophys. Acta, 1851, 1346-1352 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(8,10,12-EEZ)-conjugated linoleic acid derivative strong inhibition Nostoc punctiforme
alpha-calendic acid (8,10,12-ZEE)-conjugated linoleic acid derivative, strong inhibition Nostoc punctiforme
alpha-eleostearic acid (9,11,13-ZEE)-conjugated linoleic acid derivative, strong inhibition Nostoc punctiforme
alpha-linolenic acid 13% inhibition Nostoc punctiforme
beta-calendic acid (8,10,12-EEE)-conjugated linoleic acid derivative, complete inhibition Nostoc punctiforme
beta-eleostearic acid (9,11,13-EEE)-conjugated linoleic acid derivative, complete inhibition Nostoc punctiforme
catalpic acid (9,11,13-EEZ)-conjugated linoleic acid derivative Nostoc punctiforme
jacaric acid (8,10,12-ZEZ)-conjugated linoleic acid derivative, low inhibition Nostoc punctiforme
additional information the enzyme is potently inhibited by 8,10,12- and 9,11,13-conjugated linoleic acid derivatives, found as impurities in the linoleic acid preparation from plant, overview Nostoc punctiforme
oxidized linoleic acid 6% inhibition Nostoc punctiforme
punicic acid (9,11,13-ZEZ)-conjugated linoleic acid derivative Nostoc punctiforme

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
linoleate + O2 Nostoc punctiforme
-
(8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate
-
?

Organism

Organism UniProt Comment Textmining
Nostoc punctiforme
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
linoleate + O2
-
Nostoc punctiforme (8E,10S,12Z)-10-hydroperoxyoctadeca-8,12-dienoate
-
?

Synonyms

Synonyms Comment Organism
linoleate 10S-dioxygenase
-
Nostoc punctiforme
linoleate 10S-DOX
-
Nostoc punctiforme