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Literature summary for 1.13.11.80 extracted from
- Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine (2001), Proc. Natl. Acad. Sci. USA, 98, 14901-14906.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Amycolatopsis orientalis |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.006 | - |
(3,5-dihydroxyphenyl)acetyl-CoA | pH 7.5, 24°C | Amycolatopsis orientalis |  |
| 0.3 | - |
phenylacetyl-CoA | pH 7.5, 24°C | Amycolatopsis orientalis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Amycolatopsis orientalis | G4V4T6 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Amycolatopsis orientalis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (3,5-dihydroxyphenyl)acetyl-CoA + O2 | - |
Amycolatopsis orientalis | (3,5-dihydroxyphenyl)glyoxylate + CoA | - |
? | |
| phenylacetyl-CoA + O2 | - |
Amycolatopsis orientalis | phenylglyoxylate + CoA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DpgC | - |
Amycolatopsis orientalis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 24 | - |
assay at | Amycolatopsis orientalis |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.017 | - |
phenylacetyl-CoA | pH 7.5, 24°C | Amycolatopsis orientalis | |
| 0.17 | - |
(3,5-dihydroxyphenyl)acetyl-CoA | pH 7.5, 24°C | Amycolatopsis orientalis | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Amycolatopsis orientalis |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.06 | - |
phenylacetyl-CoA | pH 7.5, 24°C | Amycolatopsis orientalis | |
| 28.3 | - |
(3,5-dihydroxyphenyl)acetyl-CoA | pH 7.5, 24°C | Amycolatopsis orientalis | |
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Release 2023.1 (January 2023)
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