BRENDA - Enzyme Database
show all sequences of 1.13.12.16

Nitronate monooxygenase, a model for anionic flavin semiquinone intermediates in oxidative catalysis

Gadda, G.; Francis, K.; Arch. Biochem. Biophys. 493, 53-61 (2009)

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
steady-state kinetic mechanism with ethylnitronate, overview
Neurospora crassa
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
additional information
NMO contains no iron atom at the active site
Neurospora crassa
additional information
NMO contains no iron atom at the active site
Cyberlindnera saturnus
additional information
NMO contains no iron atom at the active site
Pseudomonas aeruginosa
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ethylnitronate + O2 + FMNH2
Neurospora crassa
-
acetaldehyde + nitrite + FMN + H2O
-
-
?
ethylnitronate + O2 + FMNH2
Cyberlindnera saturnus
-
acetaldehyde + nitrite + FMN + H2O
-
-
?
ethylnitronate + O2 + FMNH2
Pseudomonas aeruginosa
-
acetaldehyde + nitrite + FMN + H2O
-
-
?
ethylnitronate + O2 + FMNH2
Cyberlindnera saturnus mrakii
-
acetaldehyde + nitrite + FMN + H2O
-
-
?
additional information
Neurospora crassa
both the neutral and anionic forms of nitroalkanes act as substrates for the oxidative denitrification reaction catalyzed by Neurospora crassa NMO. NMO does not produce and release hydrogen peroxide during turnover with linear alkyl nitronates of various lengths between 2 and 6 carbon atoms or with propyl-2-nitronate. With the exception of propyl-1- and propyl-2-nitronate, there is no release of superoxide during turnover of NMO at pH 8.0 and 30°C with linear alkyl nitronates with chain lengths between 2 and 6 carbon atoms
?
-
-
?
additional information
Cyberlindnera saturnus
only alkyl nitronates are used as substrates in the oxidative denitrification reaction catalyzed by Williopsis saturnus var. mrakii NMO, nitroalkanes are no substrates. The different substrate specificity compared to other NMOs might result from the presence of a His residue in the active site and conformational differences. NMO does not produce and release hydrogen peroxide during turnover with linear alkyl nitronates of various lengths between 2 and 6 carbon atoms or with propyl-2-nitronate. With the exception of propyl-2-nitronate, there is no release of superoxide during turnover of NMO at pH 8.0 and 30°C with linear alkyl nitronates with chain lengths between 2 and 6 carbon atoms
?
-
-
?
additional information
Cyberlindnera saturnus mrakii
only alkyl nitronates are used as substrates in the oxidative denitrification reaction catalyzed by Williopsis saturnus var. mrakii NMO, nitroalkanes are no substrates. The different substrate specificity compared to other NMOs might result from the presence of a His residue in the active site and conformational differences. NMO does not produce and release hydrogen peroxide during turnover with linear alkyl nitronates of various lengths between 2 and 6 carbon atoms or with propyl-2-nitronate. With the exception of propyl-2-nitronate, there is no release of superoxide during turnover of NMO at pH 8.0 and 30°C with linear alkyl nitronates with chain lengths between 2 and 6 carbon atoms
?
-
-
?
nitroethane + O2
Neurospora crassa
-
acetaldehyde + nitrite
-
-
?
nitroethane + O2
Pseudomonas aeruginosa
-
acetaldehyde + nitrite
-
-
?
propyl-1-nitronate + O2 + FMNH2
Neurospora crassa
-
? + nitrite + FMN + H2O
-
-
?
propyl-2-nitronate + O2 + FMNH2
Neurospora crassa
-
? + nitrite + FMN + H2O
-
-
?
propyl-2-nitronate + O2 + FMNH2
Cyberlindnera saturnus
-
? + nitrite + FMN + H2O
-
-
?
propyl-2-nitronate + O2 + FMNH2
Cyberlindnera saturnus mrakii
-
? + nitrite + FMN + H2O
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Cyberlindnera saturnus
-
-
-
Cyberlindnera saturnus mrakii
-
-
-
Neurospora crassa
-
-
-
Pseudomonas aeruginosa
Q9I4V0
-
-
Reaction
Reaction
Commentary
Organism
Reaction ID
ethylnitronate + O2 = acetaldehyde + nitrite + other products
catalytic and kinetic reaction mechanism, comparison to the nitroalkane oxigenase, EC 1.7.3.1, and other flavin-dependent enzymes, ionization of nitroethane and ethylnitronate in aqueous solution, overview. Enzymatic turnover begins with the rapid equilibrium association of ethylnitronate and the enzyme. In the oxidative pathway, the transfer of a single electron oxidizes the organic substrate and reduces the enzyme-bound flavin to an anionic semiquinone species, the electron transfer occurs while the substrate radical is still bound in the active site of the enzyme. After formation of the flavosemiquinone species in the active site of NMO, the subsequent oxidation of the one electron reduced flavin occurs when molecular oxygen reacts with the anionic flavosemiquinone to yield an enzyme-associated superoxide species, with second-order rate constants
Neurospora crassa
ethylnitronate + O2 = acetaldehyde + nitrite + other products
catalytic and kinetic reaction mechanism, comparison to the nitroalkane oxygenase, EC 1.7.3.1, and other flavin-dependent enzymes, ionization of nitroethane and ethylnitronate in aqueous solution, overview
Cyberlindnera saturnus
ethylnitronate + O2 = acetaldehyde + nitrite + other products
catalytic and kinetic reaction mechanism, comparison to the nitroalkane oxygenase, EC 1.7.3.1, and other flavin-dependent enzymes, ionization of nitroethane and ethylnitronate in aqueous solution, overview
Pseudomonas aeruginosa
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
2-nitropropane + O2
-
695891
Pseudomonas aeruginosa
?
-
-
-
?
ethylnitronate + O2 + FMNH2
-
695891
Neurospora crassa
acetaldehyde + nitrite + FMN + H2O
-
-
-
?
ethylnitronate + O2 + FMNH2
-
695891
Cyberlindnera saturnus
acetaldehyde + nitrite + FMN + H2O
-
-
-
?
ethylnitronate + O2 + FMNH2
-
695891
Pseudomonas aeruginosa
acetaldehyde + nitrite + FMN + H2O
-
-
-
?
ethylnitronate + O2 + FMNH2
reaction via ethylnitronate radical. Catalytic turnover of NMO with ethylnitronate as substrate occurs through both an oxidative denitrification pathway and a non-oxidative pathway in which the anionic substrate is protonated in the active site of the enzyme to form nitroethane as a reaction product
695891
Neurospora crassa
acetaldehyde + nitrite + FMN + H2O
-
-
-
?
ethylnitronate + O2 + FMNH2
-
695891
Cyberlindnera saturnus mrakii
acetaldehyde + nitrite + FMN + H2O
-
-
-
?
additional information
both the neutral and anionic forms of nitroalkanes act as substrates for the oxidative denitrification reaction catalyzed by Neurospora crassa NMO. NMO does not produce and release hydrogen peroxide during turnover with linear alkyl nitronates of various lengths between 2 and 6 carbon atoms or with propyl-2-nitronate. With the exception of propyl-1- and propyl-2-nitronate, there is no release of superoxide during turnover of NMO at pH 8.0 and 30°C with linear alkyl nitronates with chain lengths between 2 and 6 carbon atoms
695891
Neurospora crassa
?
-
-
-
?
additional information
only alkyl nitronates are used as substrates in the oxidative denitrification reaction catalyzed by Williopsis saturnus var. mrakii NMO, nitroalkanes are no substrates. The different substrate specificity compared to other NMOs might result from the presence of a His residue in the active site and conformational differences. NMO does not produce and release hydrogen peroxide during turnover with linear alkyl nitronates of various lengths between 2 and 6 carbon atoms or with propyl-2-nitronate. With the exception of propyl-2-nitronate, there is no release of superoxide during turnover of NMO at pH 8.0 and 30°C with linear alkyl nitronates with chain lengths between 2 and 6 carbon atoms
695891
Cyberlindnera saturnus
?
-
-
-
?
additional information
only alkyl nitronates are used as substrates in the oxidative denitrification reaction catalyzed by Williopsis saturnus var. mrakii NMO, nitroalkanes are no substrates. The different substrate specificity compared to other NMOs might result from the presence of a His residue in the active site and conformational differences. NMO does not produce and release hydrogen peroxide during turnover with linear alkyl nitronates of various lengths between 2 and 6 carbon atoms or with propyl-2-nitronate. With the exception of propyl-2-nitronate, there is no release of superoxide during turnover of NMO at pH 8.0 and 30°C with linear alkyl nitronates with chain lengths between 2 and 6 carbon atoms
695891
Cyberlindnera saturnus mrakii
?
-
-
-
?
nitroethane + O2
-
695891
Neurospora crassa
acetaldehyde + nitrite
-
-
-
?
nitroethane + O2
-
695891
Pseudomonas aeruginosa
acetaldehyde + nitrite
-
-
-
?
nitroethane + O2
catalytic turnover of NMO with nitroethane as substrate occurs with oxidative and non-oxidative pathways with ethylnitronate formation and release in assays of the enzyme with the neutral substrate. The nonoxidative pathway of the enzyme with nitroethane as substrate also involves the H196-catalyzed deprotonation of the nitroalkane and the release of ethylnitronate as a reaction product
695891
Neurospora crassa
acetaldehyde + nitrite
-
-
-
?
propyl-1-nitronate + O2 + FMNH2
-
695891
Neurospora crassa
? + nitrite + FMN + H2O
-
-
-
?
propyl-2-nitronate + O2 + FMNH2
-
695891
Neurospora crassa
? + nitrite + FMN + H2O
-
-
-
?
propyl-2-nitronate + O2 + FMNH2
-
695891
Cyberlindnera saturnus
? + nitrite + FMN + H2O
-
-
-
?
propyl-2-nitronate + O2 + FMNH2
-
695891
Cyberlindnera saturnus mrakii
? + nitrite + FMN + H2O
-
-
-
?
Subunits
Subunits
Commentary
Organism
More
enzyme surface structure analysis using the structure PDB Code 2GJN
Pseudomonas aeruginosa
Synonyms
Synonyms
Commentary
Organism
NMO
-
Neurospora crassa
NMO
-
Cyberlindnera saturnus
NMO
-
Pseudomonas aeruginosa
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
assay at
Neurospora crassa
30
-
assay at
Cyberlindnera saturnus
30
-
assay at
Pseudomonas aeruginosa
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay at
Pseudomonas aeruginosa
7.4
8
assay at
Neurospora crassa
7.4
8
assay at
Cyberlindnera saturnus
Cofactor
Cofactor
Commentary
Organism
Structure
FMN
contains a tightly, but not covalently, bound flavin that is required for enzymatic activity
Neurospora crassa
FMN
contains a tightly, but not covalently, bound flavin that is required for enzymatic activity
Cyberlindnera saturnus
FMN
contains a tightly, but not covalently, bound flavin that is required for enzymatic activity
Pseudomonas aeruginosa
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
FMN
contains a tightly, but not covalently, bound flavin that is required for enzymatic activity
Neurospora crassa
FMN
contains a tightly, but not covalently, bound flavin that is required for enzymatic activity
Cyberlindnera saturnus
FMN
contains a tightly, but not covalently, bound flavin that is required for enzymatic activity
Pseudomonas aeruginosa
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
steady-state kinetic mechanism with ethylnitronate, overview
Neurospora crassa
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
additional information
NMO contains no iron atom at the active site
Neurospora crassa
additional information
NMO contains no iron atom at the active site
Cyberlindnera saturnus
additional information
NMO contains no iron atom at the active site
Pseudomonas aeruginosa
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
ethylnitronate + O2 + FMNH2
Neurospora crassa
-
acetaldehyde + nitrite + FMN + H2O
-
-
?
ethylnitronate + O2 + FMNH2
Cyberlindnera saturnus
-
acetaldehyde + nitrite + FMN + H2O
-
-
?
ethylnitronate + O2 + FMNH2
Pseudomonas aeruginosa
-
acetaldehyde + nitrite + FMN + H2O
-
-
?
ethylnitronate + O2 + FMNH2
Cyberlindnera saturnus mrakii
-
acetaldehyde + nitrite + FMN + H2O
-
-
?
additional information
Neurospora crassa
both the neutral and anionic forms of nitroalkanes act as substrates for the oxidative denitrification reaction catalyzed by Neurospora crassa NMO. NMO does not produce and release hydrogen peroxide during turnover with linear alkyl nitronates of various lengths between 2 and 6 carbon atoms or with propyl-2-nitronate. With the exception of propyl-1- and propyl-2-nitronate, there is no release of superoxide during turnover of NMO at pH 8.0 and 30°C with linear alkyl nitronates with chain lengths between 2 and 6 carbon atoms
?
-
-
?
additional information
Cyberlindnera saturnus
only alkyl nitronates are used as substrates in the oxidative denitrification reaction catalyzed by Williopsis saturnus var. mrakii NMO, nitroalkanes are no substrates. The different substrate specificity compared to other NMOs might result from the presence of a His residue in the active site and conformational differences. NMO does not produce and release hydrogen peroxide during turnover with linear alkyl nitronates of various lengths between 2 and 6 carbon atoms or with propyl-2-nitronate. With the exception of propyl-2-nitronate, there is no release of superoxide during turnover of NMO at pH 8.0 and 30°C with linear alkyl nitronates with chain lengths between 2 and 6 carbon atoms
?
-
-
?
additional information
Cyberlindnera saturnus mrakii
only alkyl nitronates are used as substrates in the oxidative denitrification reaction catalyzed by Williopsis saturnus var. mrakii NMO, nitroalkanes are no substrates. The different substrate specificity compared to other NMOs might result from the presence of a His residue in the active site and conformational differences. NMO does not produce and release hydrogen peroxide during turnover with linear alkyl nitronates of various lengths between 2 and 6 carbon atoms or with propyl-2-nitronate. With the exception of propyl-2-nitronate, there is no release of superoxide during turnover of NMO at pH 8.0 and 30°C with linear alkyl nitronates with chain lengths between 2 and 6 carbon atoms
?
-
-
?
nitroethane + O2
Neurospora crassa
-
acetaldehyde + nitrite
-
-
?
nitroethane + O2
Pseudomonas aeruginosa
-
acetaldehyde + nitrite
-
-
?
propyl-1-nitronate + O2 + FMNH2
Neurospora crassa
-
? + nitrite + FMN + H2O
-
-
?
propyl-2-nitronate + O2 + FMNH2
Neurospora crassa
-
? + nitrite + FMN + H2O
-
-
?
propyl-2-nitronate + O2 + FMNH2
Cyberlindnera saturnus
-
? + nitrite + FMN + H2O
-
-
?
propyl-2-nitronate + O2 + FMNH2
Cyberlindnera saturnus mrakii
-
? + nitrite + FMN + H2O
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
2-nitropropane + O2
-
695891
Pseudomonas aeruginosa
?
-
-
-
?
ethylnitronate + O2 + FMNH2
-
695891
Neurospora crassa
acetaldehyde + nitrite + FMN + H2O
-
-
-
?
ethylnitronate + O2 + FMNH2
-
695891
Cyberlindnera saturnus
acetaldehyde + nitrite + FMN + H2O
-
-
-
?
ethylnitronate + O2 + FMNH2
-
695891
Pseudomonas aeruginosa
acetaldehyde + nitrite + FMN + H2O
-
-
-
?
ethylnitronate + O2 + FMNH2
reaction via ethylnitronate radical. Catalytic turnover of NMO with ethylnitronate as substrate occurs through both an oxidative denitrification pathway and a non-oxidative pathway in which the anionic substrate is protonated in the active site of the enzyme to form nitroethane as a reaction product
695891
Neurospora crassa
acetaldehyde + nitrite + FMN + H2O
-
-
-
?
ethylnitronate + O2 + FMNH2
-
695891
Cyberlindnera saturnus mrakii
acetaldehyde + nitrite + FMN + H2O
-
-
-
?
additional information
both the neutral and anionic forms of nitroalkanes act as substrates for the oxidative denitrification reaction catalyzed by Neurospora crassa NMO. NMO does not produce and release hydrogen peroxide during turnover with linear alkyl nitronates of various lengths between 2 and 6 carbon atoms or with propyl-2-nitronate. With the exception of propyl-1- and propyl-2-nitronate, there is no release of superoxide during turnover of NMO at pH 8.0 and 30°C with linear alkyl nitronates with chain lengths between 2 and 6 carbon atoms
695891
Neurospora crassa
?
-
-
-
?
additional information
only alkyl nitronates are used as substrates in the oxidative denitrification reaction catalyzed by Williopsis saturnus var. mrakii NMO, nitroalkanes are no substrates. The different substrate specificity compared to other NMOs might result from the presence of a His residue in the active site and conformational differences. NMO does not produce and release hydrogen peroxide during turnover with linear alkyl nitronates of various lengths between 2 and 6 carbon atoms or with propyl-2-nitronate. With the exception of propyl-2-nitronate, there is no release of superoxide during turnover of NMO at pH 8.0 and 30°C with linear alkyl nitronates with chain lengths between 2 and 6 carbon atoms
695891
Cyberlindnera saturnus
?
-
-
-
?
additional information
only alkyl nitronates are used as substrates in the oxidative denitrification reaction catalyzed by Williopsis saturnus var. mrakii NMO, nitroalkanes are no substrates. The different substrate specificity compared to other NMOs might result from the presence of a His residue in the active site and conformational differences. NMO does not produce and release hydrogen peroxide during turnover with linear alkyl nitronates of various lengths between 2 and 6 carbon atoms or with propyl-2-nitronate. With the exception of propyl-2-nitronate, there is no release of superoxide during turnover of NMO at pH 8.0 and 30°C with linear alkyl nitronates with chain lengths between 2 and 6 carbon atoms
695891
Cyberlindnera saturnus mrakii
?
-
-
-
?
nitroethane + O2
-
695891
Neurospora crassa
acetaldehyde + nitrite
-
-
-
?
nitroethane + O2
-
695891
Pseudomonas aeruginosa
acetaldehyde + nitrite
-
-
-
?
nitroethane + O2
catalytic turnover of NMO with nitroethane as substrate occurs with oxidative and non-oxidative pathways with ethylnitronate formation and release in assays of the enzyme with the neutral substrate. The nonoxidative pathway of the enzyme with nitroethane as substrate also involves the H196-catalyzed deprotonation of the nitroalkane and the release of ethylnitronate as a reaction product
695891
Neurospora crassa
acetaldehyde + nitrite
-
-
-
?
propyl-1-nitronate + O2 + FMNH2
-
695891
Neurospora crassa
? + nitrite + FMN + H2O
-
-
-
?
propyl-2-nitronate + O2 + FMNH2
-
695891
Neurospora crassa
? + nitrite + FMN + H2O
-
-
-
?
propyl-2-nitronate + O2 + FMNH2
-
695891
Cyberlindnera saturnus
? + nitrite + FMN + H2O
-
-
-
?
propyl-2-nitronate + O2 + FMNH2
-
695891
Cyberlindnera saturnus mrakii
? + nitrite + FMN + H2O
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
More
enzyme surface structure analysis using the structure PDB Code 2GJN
Pseudomonas aeruginosa
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
30
-
assay at
Neurospora crassa
30
-
assay at
Cyberlindnera saturnus
30
-
assay at
Pseudomonas aeruginosa
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay at
Pseudomonas aeruginosa
7.4
8
assay at
Neurospora crassa
7.4
8
assay at
Cyberlindnera saturnus
Other publictions for EC 1.13.12.16
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745219
Vercammen
Pseudomonas aeruginosa LysR P ...
Pseudomonas aeruginosa
J. Bacteriol.
197
1026-1039
2015
-
-
1
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
-
5
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
745306
Salvi
The combined structural and k ...
Pseudomonas aeruginosa
J. Biol. Chem.
289
23764-23775
2014
-
-
1
1
-
-
-
4
-
-
-
1
-
10
-
-
1
1
-
-
-
-
8
1
5
1
-
-
3
1
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
4
-
-
-
1
-
-
-
1
-
-
-
-
8
1
1
-
-
3
1
-
-
-
-
3
3
-
6
6
727018
Smitherman
Evidence for a transient perox ...
Cyberlindnera saturnus
Biochemistry
52
2694-2704
2013
-
-
-
-
-
-
-
6
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
1
2
-
-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
5
1
-
-
-
-
-
-
-
6
6
728077
Klinkenberg
Rv1894c is a novel hypoxia-ind ...
Mycobacterium tuberculosis
J. Infect. Dis.
207
1525-1534
2013
-
-
1
-
1
-
1
-
-
-
-
-
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10
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