Application | Comment | Organism |
---|---|---|
analysis | analysis of luciferase inhibitors by quantitative high-throughput screening and comparison of and structure-activity relationship using various luciferase-based detection reagents | Renilla reniformis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2Z)-3-[(2-bromophenyl)amino]-1-pyridin-2-ylprop-2-en-1-one | - |
Renilla reniformis | |
(2Z)-3-[[4-(dimethylamino)cyclohexa-1,5-dien-1-yl]amino]-1-phenylprop-2-en-1-one | - |
Renilla reniformis | |
(3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-1,3-dihydro-2H-indol-2-one | common name SU4312 | Renilla reniformis | |
2-(4-ethoxyphenyl)-4-[(4-methylpiperazin-1-yl)carbonyl]quinoline | - |
Renilla reniformis | |
2-(4-ethoxyphenyl)-4-[(4-pyridin-2-ylpiperazin-1-yl)carbonyl]quinoline | - |
Renilla reniformis | |
2-(4-methylphenyl)-4-[(4-pyrimidin-2-ylpiperazin-1-yl)carbonyl]quinoline | - |
Renilla reniformis | |
2-(5-naphthalen-2-yl-1,2,4-oxadiazol-3-yl)pyridine | - |
Renilla reniformis | |
2-hydroxy-N'-[(1E)-(2-hydroxyphenyl)methylidene]benzohydrazide | common name SCS | Renilla reniformis | |
2-[5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine | - |
Renilla reniformis | |
4-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-2-(4-ethoxyphenyl)quinoline | - |
Renilla reniformis | |
4-amino-6-[(E)-[4'-[(Z)-(8-amino-1-hydroxy-5,7-disulfonato-6,7-dihydronaphthalen-2-yl)diazenyl]-3-methylbiphenyl-4-yl]diazenyl]-5-hydroxy-2,3-dihydronaphthalene-1,3-disulfonate | common name Evans Blue | Renilla reniformis | |
4-[1-(1,3-benzothiazol-2-yl)-2-(4-methylpiperazin-1-yl)-2-oxoethyl]phenol | - |
Renilla reniformis | |
6-methyl-2-[(Z)-phenyldiazenyl]pyridin-3-ol | common name SIB1757 | Renilla reniformis | |
ethyl 4-[[2-(4-ethoxyphenyl)quinolin-4-yl]carbonyl]piperazine-1-carboxylate | - |
Renilla reniformis | |
additional information | structure-activity relationship of luciferase inhibitors determined by quantitative high-throughput screening. Comparison of effect on various luciferase-based detection reagents | Renilla reniformis | |
N'-(3-chlorophenyl)-N-[(1Z)-(3-chlorophenyl)methylidene]imidoformamide | common name DCB | Renilla reniformis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Renilla reniformis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-luciferin + O2 + ATP | - |
Renilla reniformis | oxidized D-luciferin + CO2 + H2O + AMP + diphosphate + hv | - |
? |
Synonyms | Comment | Organism |
---|---|---|
firefly luciferase | - |
Renilla reniformis |
Luc | - |
Renilla reniformis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.01 | - |
- |
Renilla reniformis | 4-amino-6-[(E)-[4'-[(Z)-(8-amino-1-hydroxy-5,7-disulfonato-6,7-dihydronaphthalen-2-yl)diazenyl]-3-methylbiphenyl-4-yl]diazenyl]-5-hydroxy-2,3-dihydronaphthalene-1,3-disulfonate | |
0.011 | - |
- |
Renilla reniformis | (2Z)-3-[[4-(dimethylamino)cyclohexa-1,5-dien-1-yl]amino]-1-phenylprop-2-en-1-one | |
0.011 | - |
- |
Renilla reniformis | 2-(4-ethoxyphenyl)-4-[(4-pyridin-2-ylpiperazin-1-yl)carbonyl]quinoline | |
0.011 | - |
- |
Renilla reniformis | 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-2-(4-ethoxyphenyl)quinoline | |
0.011 | - |
pH 7.2, 22°C | Renilla reniformis | (2Z)-3-[[4-(dimethylamino)cyclohexa-1,5-dien-1-yl]amino]-1-phenylprop-2-en-1-one | |
0.011 | - |
pH 7.2, 22°C | Renilla reniformis | 2-(4-ethoxyphenyl)-4-[(4-pyridin-2-ylpiperazin-1-yl)carbonyl]quinoline | |
0.011 | - |
pH 7.2, 22°C | Renilla reniformis | 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)-2-(4-ethoxyphenyl)quinoline | |
0.019 | - |
- |
Renilla reniformis | (3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-1,3-dihydro-2H-indol-2-one | |
0.019 | - |
pH 7.2, 22°C | Renilla reniformis | (3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-1,3-dihydro-2H-indol-2-one | |
0.02 | - |
- |
Renilla reniformis | 2-hydroxy-N'-[(1E)-(2-hydroxyphenyl)methylidene]benzohydrazide | |
0.02 | - |
- |
Renilla reniformis | ethyl 4-[[2-(4-ethoxyphenyl)quinolin-4-yl]carbonyl]piperazine-1-carboxylate | |
0.02 | - |
pH 7.2, 22°C | Renilla reniformis | 2-hydroxy-N'-[(1E)-(2-hydroxyphenyl)methylidene]benzohydrazide | |
0.02 | - |
pH 7.2, 22°C | Renilla reniformis | ethyl 4-[[2-(4-ethoxyphenyl)quinolin-4-yl]carbonyl]piperazine-1-carboxylate | |
0.0225 | - |
- |
Renilla reniformis | 4-[1-(1,3-benzothiazol-2-yl)-2-(4-methylpiperazin-1-yl)-2-oxoethyl]phenol | |
0.0225 | - |
pH 7.2, 22°C | Renilla reniformis | 4-[1-(1,3-benzothiazol-2-yl)-2-(4-methylpiperazin-1-yl)-2-oxoethyl]phenol | |
0.025 | - |
- |
Renilla reniformis | 2-(5-naphthalen-2-yl-1,2,4-oxadiazol-3-yl)pyridine | |
0.025 | - |
IC50 above 0.025 mM | Renilla reniformis | 2-(4-ethoxyphenyl)-4-[(4-methylpiperazin-1-yl)carbonyl]quinoline | |
0.025 | - |
IC50 above 0.025 mM | Renilla reniformis | 2-(4-methylphenyl)-4-[(4-pyrimidin-2-ylpiperazin-1-yl)carbonyl]quinoline | |
0.025 | - |
pH 7.2, 22°C | Renilla reniformis | 2-(5-naphthalen-2-yl-1,2,4-oxadiazol-3-yl)pyridine | |
0.036 | - |
- |
Renilla reniformis | 6-methyl-2-[(Z)-phenyldiazenyl]pyridin-3-ol | |
0.05 | - |
IC50 above 0.05 mM | Renilla reniformis | (2Z)-3-[(2-bromophenyl)amino]-1-pyridin-2-ylprop-2-en-1-one | |
0.05 | - |
IC50 above 0.05 mM | Renilla reniformis | 2-[5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl]pyridine | |
0.05 | - |
IC50 above 0.05 mM | Renilla reniformis | N'-(3-chlorophenyl)-N-[(1Z)-(3-chlorophenyl)methylidene]imidoformamide |