Activating Compound | Comment | Organism | Structure |
---|---|---|---|
catalase | - |
Rattus norvegicus | |
Microsomal preparation | increase of activity | Rattus norvegicus | |
NADPH | NADPH-regenerating system, increase of activity, no absolute requirement | Rattus norvegicus | |
nicotinamide | increase of activity | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ascorbate | - |
Rattus norvegicus | |
FMN | in high concentrations | Rattus norvegicus | |
H2O2 | - |
Rattus norvegicus | |
Quinacrine | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Rattus norvegicus | 5737 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | requirement | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Oxidation Stability | Organism |
---|---|
O2, irreversible inactivation during preincubation | Rattus norvegicus |
Purification (Comment) | Organism |
---|---|
partial | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
additional information | no activity found: muscle, kidney | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0014 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-trimethylaminopropionic acid + 2-oxoglutarate + O2 | 20% of the hydroxylation rate of gamma-butyrobetaine | Rattus norvegicus | ? | - |
? | |
4-dimethylaminobutyric acid + 2-oxoglutarate + O2 | poor substrate | Rattus norvegicus | 4-dimethylamino-3-hydroxybutyric acid + succinate + CO2 | - |
? | |
4-trimethylammoniobutanoate + 2-oxoglutarate + O2 | - |
Rattus norvegicus | 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2 | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
60 | - |
complete inactivation after 15 min | Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 8.4 | half-maximal activity at pH 6.0 and 8.4, partially purified preparation | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ascorbate | - |
Rattus norvegicus |