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Literature summary for 1.14.11.16 extracted from

  • Iwagami, Y.; Huang, C.K.; Olsen, M.J.; Thomas, J.M.; Jang, G.; Kim, M.; Lin, Q.; Carlson, R.I.; Wagner, C.E.; Dong, X.; Wands, J.R.
    Aspartate beta-hydroxylase modulates cellular senescence through glycogen synthase kinase 3beta in hepatocellular carcinoma (2016), Hepatology, 63, 1213-1226 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q12797
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Source Tissue

Source Tissue Comment Organism Textmining
hepatoma cell line
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
aspartate beta-hydroxylase
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 Homo sapiens
ASPH
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 Homo sapiens

General Information

General Information Comment Organism
drug target the enzyme can be a potential therapeutic target and a 2nd generation beta-hydroxylase inhibitor is an effective anti-tumor agent against intrahepatic hepatocellular carcinoma growth and progression partially through the induction of cellular senescence Homo sapiens
physiological function aspartate beta-hydroxylase modulates cellular senescence through glycogen synthase kinase 3beta in hepatocellular carcinoma. shRNA-mediated knockdown and CRISPR/Cas9-mediated knockout of aspartate beta-hydroxylase as well as enzymatic inhibition of the enzyme guide human hepatocellular carcinoma cells to undergo cellular senescence. Inhibition of aspartate beta-hydroxylase activity induces senescence as mediated through phosphorylation of GSK3beta. In addition, aspartate beta-hydroxylase binding to GSK3beta inhibits its phosphorylation (inactivation) and thus blocks the signal transduction from its upstream kinases Homo sapiens