Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
86000 | - |
- |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q12797 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreatic ductal adenocarcinoma cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ASPH | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme is highly overexpressed in pancreatic cancer. Upregulation of the enzyme confers a malignant phenotype characterized by enhanced cell proliferation, migration, invasion and colony formation in vitro as well as pancreatic cancer tumor growth in vivo. The transforming properties of aspartate beta-hydroxylase depend on enzymatic activity | up |
General Information | Comment | Organism |
---|---|---|
drug target | a small molecule inhibitor (MO-I-1100) of beta-hydroxylase activity is developed and found to reduce pancreatic cancer growth by downregulating the Notch signaling pathway | Homo sapiens |
metabolism | the enzyme catalyzes the hydroxylation of epidermal growth factor (EGF)-like repeats in Notch receptors and ligands. It is highly overexpressed in pancreatic cancer. The upregulation confers a malignant phenotype characterized by enhanced cell proliferation, migration, invasion and colony formation in vitro as well as pancreatic cancer tumor growth in vivo. The transforming properties of aspartate beta-hydroxylase depend on enzymatic activity. The enzyme links pancreatic cancer growth factor signaling cascades to Notch activation | Homo sapiens |