Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.16 extracted from

  • Brewitz, L.; Tumber, A.; Pfeffer, I.; McDonough, M.A.; Schofield, C.J.
    Aspartate/asparagine-beta-hydroxylase a high-throughput mass spectrometric assay for discovery of small molecule inhibitors (2020), Sci. Rep., 10, 8650 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
N-terminally His6-tagged human AspH315-758 (His6-AspH315-758) is produced in Escherichia coli BL21 (DE3) cells using a pET-28a(+) vector Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop vapor diffusion method at 4°C Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
AS-8351
-
Homo sapiens
ciclopirox olamine
-
Homo sapiens
Co2+
-
Homo sapiens
daprodustat
-
Homo sapiens
deferasirox
-
Homo sapiens
deferiprone
-
Homo sapiens
deferoxamine mesylate
-
Homo sapiens
desidustat
-
Homo sapiens
ebselen
-
Homo sapiens
GSK-J1
-
Homo sapiens
IOX1
-
Homo sapiens
JIB-04
-
Homo sapiens
L-mimosine
-
Homo sapiens
ML324
-
Homo sapiens
Mn2+
-
Homo sapiens
molidustat
-
Homo sapiens
Ni2+
-
Homo sapiens
NOFD
-
Homo sapiens
PBIT
-
Homo sapiens
roxadustat
-
Homo sapiens
TC-E 5002
-
Homo sapiens
vadadustat
-
Homo sapiens
Zn2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptide-L-aspartate + 2-oxoglutarate + O2 Homo sapiens the enzyme catalyses hydroxylation of asparaginyl- and aspartyl-residues in epidermal growth factor-like domains peptide-3-hydroxy-L-aspartate + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q12797
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptide-L-aspartate + 2-oxoglutarate + O2
-
Homo sapiens peptide-3-hydroxy-L-aspartate + succinate + CO2
-
?
peptide-L-aspartate + 2-oxoglutarate + O2 the enzyme catalyses hydroxylation of asparaginyl- and aspartyl-residues in epidermal growth factor-like domains Homo sapiens peptide-3-hydroxy-L-aspartate + succinate + CO2
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00005
-
pH 7.5, 20°C Homo sapiens Zn2+
0.00007
-
pH 7.5, 20°C Homo sapiens IOX1
0.00012
-
pH 7.5, 20°C Homo sapiens ebselen
0.00014
-
pH 7.5, 20°C Homo sapiens PBIT
0.00017
-
pH 7.5, 20°C Homo sapiens Ni2+
0.00039
-
pH 7.5, 20°C Homo sapiens Co2+
0.00208
-
pH 7.5, 20°C Homo sapiens deferasirox
0.00307
-
pH 7.5, 20°C Homo sapiens AS-8351
0.00316
-
pH 7.5, 20°C Homo sapiens deferoxamine mesylate
0.00424
-
pH 7.5, 20°C Homo sapiens JIB-04
0.00439
-
pH 7.5, 20°C Homo sapiens ciclopirox olamine
0.00439
-
pH 7.5, 20°C Homo sapiens vadadustat
0.00465
-
pH 7.5, 20°C Homo sapiens ML324
0.00489
-
pH 7.5, 20°C Homo sapiens deferiprone
0.00506
-
pH 7.5, 20°C Homo sapiens Mn2+
0.00506
-
pH 7.5, 20°C Homo sapiens L-mimosine
0.00666
-
pH 7.5, 20°C Homo sapiens TC-E 5002
0.0111
-
pH 7.5, 20°C Homo sapiens daprodustat
0.01342
-
pH 7.5, 20°C Homo sapiens molidustat
0.01547
-
pH 7.5, 20°C Homo sapiens NOFD
0.0163
-
pH 7.5, 20°C Homo sapiens desidustat
0.0194
-
pH 7.5, 20°C Homo sapiens roxadustat
0.129
-
pH 7.5, 20°C Homo sapiens GSK-J1