Cloned (Comment) | Organism |
---|---|
N-terminally His6-tagged human AspH315-758 (His6-AspH315-758) is produced in Escherichia coli BL21 (DE3) cells using a pET-28a(+) vector | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
sitting drop vapor diffusion method at 4°C | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AS-8351 | - |
Homo sapiens | |
ciclopirox olamine | - |
Homo sapiens | |
Co2+ | - |
Homo sapiens | |
daprodustat | - |
Homo sapiens | |
deferasirox | - |
Homo sapiens | |
deferiprone | - |
Homo sapiens | |
deferoxamine mesylate | - |
Homo sapiens | |
desidustat | - |
Homo sapiens | |
ebselen | - |
Homo sapiens | |
GSK-J1 | - |
Homo sapiens | |
IOX1 | - |
Homo sapiens | |
JIB-04 | - |
Homo sapiens | |
L-mimosine | - |
Homo sapiens | |
ML324 | - |
Homo sapiens | |
Mn2+ | - |
Homo sapiens | |
molidustat | - |
Homo sapiens | |
Ni2+ | - |
Homo sapiens | |
NOFD | - |
Homo sapiens | |
PBIT | - |
Homo sapiens | |
roxadustat | - |
Homo sapiens | |
TC-E 5002 | - |
Homo sapiens | |
vadadustat | - |
Homo sapiens | |
Zn2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptide-L-aspartate + 2-oxoglutarate + O2 | Homo sapiens | the enzyme catalyses hydroxylation of asparaginyl- and aspartyl-residues in epidermal growth factor-like domains | peptide-3-hydroxy-L-aspartate + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q12797 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptide-L-aspartate + 2-oxoglutarate + O2 | - |
Homo sapiens | peptide-3-hydroxy-L-aspartate + succinate + CO2 | - |
? | |
peptide-L-aspartate + 2-oxoglutarate + O2 | the enzyme catalyses hydroxylation of asparaginyl- and aspartyl-residues in epidermal growth factor-like domains | Homo sapiens | peptide-3-hydroxy-L-aspartate + succinate + CO2 | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00005 | - |
pH 7.5, 20°C | Homo sapiens | Zn2+ | |
0.00007 | - |
pH 7.5, 20°C | Homo sapiens | IOX1 | |
0.00012 | - |
pH 7.5, 20°C | Homo sapiens | ebselen | |
0.00014 | - |
pH 7.5, 20°C | Homo sapiens | PBIT | |
0.00017 | - |
pH 7.5, 20°C | Homo sapiens | Ni2+ | |
0.00039 | - |
pH 7.5, 20°C | Homo sapiens | Co2+ | |
0.00208 | - |
pH 7.5, 20°C | Homo sapiens | deferasirox | |
0.00307 | - |
pH 7.5, 20°C | Homo sapiens | AS-8351 | |
0.00316 | - |
pH 7.5, 20°C | Homo sapiens | deferoxamine mesylate | |
0.00424 | - |
pH 7.5, 20°C | Homo sapiens | JIB-04 | |
0.00439 | - |
pH 7.5, 20°C | Homo sapiens | ciclopirox olamine | |
0.00439 | - |
pH 7.5, 20°C | Homo sapiens | vadadustat | |
0.00465 | - |
pH 7.5, 20°C | Homo sapiens | ML324 | |
0.00489 | - |
pH 7.5, 20°C | Homo sapiens | deferiprone | |
0.00506 | - |
pH 7.5, 20°C | Homo sapiens | Mn2+ | |
0.00506 | - |
pH 7.5, 20°C | Homo sapiens | L-mimosine | |
0.00666 | - |
pH 7.5, 20°C | Homo sapiens | TC-E 5002 | |
0.0111 | - |
pH 7.5, 20°C | Homo sapiens | daprodustat | |
0.01342 | - |
pH 7.5, 20°C | Homo sapiens | molidustat | |
0.01547 | - |
pH 7.5, 20°C | Homo sapiens | NOFD | |
0.0163 | - |
pH 7.5, 20°C | Homo sapiens | desidustat | |
0.0194 | - |
pH 7.5, 20°C | Homo sapiens | roxadustat | |
0.129 | - |
pH 7.5, 20°C | Homo sapiens | GSK-J1 |