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Literature summary for 1.14.11.18 extracted from

  • Zomer, A.W.M.; Jansen, G.A.; Van der Burg, B.; Verhoeven, N.M.; Jakobs, C.; Van der Saag, P.T.; Wanders, R.J.A.; Poll-The, B.T.
    Phytanoyl-CoA hydroxylase activity is induced by phytanic acid (2000), Eur. J. Biochem., 267, 4063-4067.
    View publication on PubMed
Search for more literature for 1.14.11.18

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-
Mus musculus
-
 mouse
-
Platyrrhini
-
-
-
Rattus norvegicus
-
 rat
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic cell line embryonic carcinoma cell line Mus musculus
-
hepatoma cell line
-
 Homo sapiens
-
hepatoma cell line
-
 Rattus norvegicus
-
kidney
-
 Homo sapiens
-
kidney
-
 Platyrrhini
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000001
-
 in kidney cell line COS-1, activity can be induced 4fold by phytanic acid Platyrrhini
0.0000018
-
 in embryonic carcinoma cell line P19-EC, activity can be induced 4fold by phytanic acid Mus musculus
0.000002
-
 in kidney cell line 293, activity can be induced 4fold by phytanic acid Homo sapiens
0.0000031
-
 in hepatoma cell line HepG2, no induction by phytanic acid Homo sapiens
0.000024
-
 in hepatoma cell line FaO, activity can be induced 2.5fold by phytanic acid Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phytanoyl-CoA + 2-oxoglutarate + O2
-
 Homo sapiens alpha-hydroxyphytanoyl-CoA + succinate + CO2
-
 ?
phytanoyl-CoA + 2-oxoglutarate + O2
-
 Rattus norvegicus alpha-hydroxyphytanoyl-CoA + succinate + CO2
-
 ?