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Literature summary for 1.14.11.2 extracted from

  • Tryggvason, K.; Risteli, J.; Kivirikko, K.I.
    Separation of prolyl 3-hydroxylase and 4-hydroxylase activities and the 4-hydroxyproline requirement for synthesis of 3-hydroxyproline (1977), Biochem. Biophys. Res. Commun., 76, 275-281.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
dithiothreitol powerful inhibitor at 1 mM Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Sprague-Dawley strain
-
Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley strain
-

Purification (Commentary)

Purification (Comment) Organism
separation of 4-hydroxylase activity from 3-hydroxylase activity using affinity chromatography and gel filtration Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information thermal denaturing of the triple-helical conformation of the substrate before hydroxylation Rattus norvegicus ?
-
?
additional information thermal denaturing of the triple-helical conformation of the substrate before hydroxylation Rattus norvegicus Sprague-Dawley ?
-
?
protocollagen + 2-oxoglutarate + O2
-
Rattus norvegicus 4-hydroxyproline containing protocollagen + succinate + CO2
-
?
protocollagen + 2-oxoglutarate + O2
-
Rattus norvegicus Sprague-Dawley 4-hydroxyproline containing protocollagen + succinate + CO2
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus