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Literature summary for 1.14.11.2 extracted from

  • Tuckerman, J.R.; Zhao, Y.; Hewitson, K.S.; Tian, Y.M.; Pugh, C.W.; Ratcliffe, P.J.; Mole, D.R.
    Determination and comparison of specific activity of the HIF-prolyl hydroxylases (2004), FEBS Lett., 576, 145-150.
    View publication on PubMed
Search for more literature for 1.14.11.2

Activating Compound

Activating Compound Comment Organism Structure
O2 activated by oxygen Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Sf9 insect cells, HEK293T cells, in vitro transcription/translation in rabbit reticulocyte lysate Homo sapiens
in vitro transcription/translation in rabbit reticulocyte lysate Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxia-inducible factor L-proline + 2-oxoglutarate + O2 Homo sapiens
-
 hypoxia inducible factor trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q96KS0
-
-
Homo sapiens Q9H6Z9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxia-inducible factor L-proline + 2-oxoglutarate + O2
-
 Homo sapiens hypoxia inducible factor trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
PHD1
-
 Homo sapiens
PHD2
-
 Homo sapiens
PHD3
-
 Homo sapiens
prolyl hydroxylase domain containing protein
-
 Homo sapiens