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Literature summary for 1.14.11.2 extracted from

  • Hirsila, M.; Koivunen, P.; Gunzler, V.; Kivirikko, K.I.; Myllyharju, J.
    Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor (2003), J. Biol. Chem., 278, 30772-30780.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ascorbate required for activity Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Sf9 insect cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
R367K no activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-carboxy-4-oxo-3,4-dihydro-1,10-phenanthroline
-
Homo sapiens
3-hydroxypyridine-2-carbonyl-glycine
-
Homo sapiens
N-[(6-chloro-3-hydroxyquinolin-2-yl)carbonyl]glycine
-
Homo sapiens
oxalglycine
-
Homo sapiens
Pyridine-2,4-dicarboxylate
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.006
-
DLDLEMLAPYIPMDDDFQLRSFDQ
-
Homo sapiens
0.007
-
DLEMLAPYIPMDDDFQL
-
Homo sapiens
0.007
-
DLDLEMLAPYIPMDDDFQL
-
Homo sapiens
0.007
-
EMLAPYIPMDDDFQL
-
Homo sapiens
0.007
-
DLDLEMLAPYIPMDDDF
-
Homo sapiens
0.008
-
DLDLEMLAPYIPMDDDFQL
-
Homo sapiens
0.008
-
DLDLEMLAPYIPMDDDFQLRSFDQ
-
Homo sapiens
0.009
-
DLDLEMLAPYIPMDD
-
Homo sapiens
0.01
-
DLDLEMLAPAIPMDDDFQL C-terminal hydroxylation site of HIF-1alpha Homo sapiens
0.014
-
DLEMLAPYIPMDDDFQL
-
Homo sapiens
0.015
-
LAPYIPMDDDFQL
-
Homo sapiens
0.02
-
DLDLEMLAPAIPMDDDFQL C-terminal hydroxylation site of HIF-1alpha Homo sapiens
0.02
-
DLDLEMLAPGIPMDDDFQL C-terminal hydroxylation site of HIF-1alpha Homo sapiens
0.03
-
DLDLEMLAPYIPMD
-
Homo sapiens
0.035
-
EMLAPYIPMDDDFQL
-
Homo sapiens
0.05
-
DLDLEMLAPYIPMDDDF
-
Homo sapiens
0.05
-
DLDLEMLAPAIPMDDDFQLRSFDQ
-
Homo sapiens
0.055
-
2-oxoglutarate
-
Homo sapiens
0.06
-
2-oxoglutarate
-
Homo sapiens
0.06
-
DLDLEMLAPYIPMDD
-
Homo sapiens
0.07
-
DLDLEMLAPYIPMDDDF
-
Homo sapiens
0.08
-
EMLAPYIPMDDDFQL
-
Homo sapiens
0.1
-
DLDLEMLAPYIPMDD
-
Homo sapiens
0.1
-
DLDLEMLAPYIPMD
-
Homo sapiens
0.13
-
DALTLLAPAAGDTIISLFG N-terminal hydroxylation site of HIF-1alpha Homo sapiens
0.14
-
O2
-
Homo sapiens
0.14
-
ascorbate
-
Homo sapiens
0.17
-
ascorbate
-
Homo sapiens
0.18
-
ascorbate
-
Homo sapiens
0.23
-
O2
-
Homo sapiens
0.38
-
DALTLLAPAAGDTIISLFG N-terminal hydroxylation site of HIF-1alpha Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required for activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxia-inducible factor L-proline + 2-oxoglutarate + O2 Homo sapiens
-
hypoxia inducible factor trans-4-hydroxy-L-proline + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96KS0
-
-
Homo sapiens Q9GZT9
-
-
Homo sapiens Q9H6Z9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
heart
-
Homo sapiens
-
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
lung
-
Homo sapiens
-
placenta
-
Homo sapiens
-
skeletal muscle
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + O2 + ascorbate
-
Homo sapiens succinate + dehydroascorbate + CO2 + H2O
-
?
DALTLLAPAAGDTIISLFG + 2-oxoglutarate + O2
-
Homo sapiens DALTLLA-((4R)-4-hydroxy-L-proline)-AAGDTIISLFG + succinate + CO2
-
?
DLDLEMLAPAIPMDDDFQL + 2-oxoglutarate + O2
-
Homo sapiens DLDLEMLA-((4R)-4-hydroxy-L-proline)-AIPMDDDFQL + succinate + CO2
-
?
DLDLEMLAPAIPMDDDFQLRSFDQ + 2-oxoglutarate + O2
-
Homo sapiens DLDLEMLAPAIPMDDDFQLRSFDQ trans-4-hydroxy-L-proline + succinate + CO2
-
?
DLDLEMLAPGIPMDDDFQL + 2-oxoglutarate + O2
-
Homo sapiens DLDLEMLAPGIPMDDDFQL trans-4-hydroxy-L-proline + succinate + CO2
-
?
DLDLEMLAPYIPMD + 2-oxoglutarate + O2
-
Homo sapiens DLDLEMLAPYIPMD trans-4-hydroxy-L-proline + succinate + CO2
-
?
DLDLEMLAPYIPMDD + 2-oxoglutarate + O2
-
Homo sapiens DLDLEMLAPYIPMDD trans-4-hydroxy-L-proline + succinate + CO2
-
?
DLDLEMLAPYIPMDDDF + 2-oxoglutarate + O2
-
Homo sapiens DLDLEMLAPYIPMDDDF trans-4-hydroxy-L-proline + succinate + CO2
-
?
DLDLEMLAPYIPMDDDFQL + 2-oxoglutarate + O2
-
Homo sapiens DLDLEMLAPYIPMDDDFQL trans-4-hydroxy-L-proline + succinate + CO2
-
?
DLDLEMLAPYIPMDDDFQLRSFDQ + 2-oxoglutarate + O2
-
Homo sapiens DLDLEMLAPYIPMDDDFQLRSFDQ trans-4-hydroxy-L-proline + succinate + CO2
-
?
DLEMLAPYIPMDDDFQL + 2-oxoglutarate + O2
-
Homo sapiens DLEMLA-((4R)-4-hydroxy-L-proline)-YIPMDDDFQL + succinate + CO2
-
?
EMLAPYIPMDDDFQL + 2-oxoglutarate + O2
-
Homo sapiens EMLAPYIPMDDDFQL trans-4-hydroxy-L-proline + succinate + CO2
-
?
hypoxia-inducible factor L-proline + 2-oxoglutarate + O2
-
Homo sapiens hypoxia inducible factor trans-4-hydroxy-L-proline + succinate + CO2
-
?
LAPYIPMDDDFQL + 2-oxoglutarate + O2
-
Homo sapiens LAPYIPMDDDFQL trans-4-hydroxy-L-proline + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
HIF-P4H-1
-
Homo sapiens
HIF-P4H-2
-
Homo sapiens
HIF-P4H-3
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0002
-
N-[(6-chloro-3-hydroxyquinolin-2-yl)carbonyl]glycine
-
Homo sapiens
0.0008
-
N-[(6-chloro-3-hydroxyquinolin-2-yl)carbonyl]glycine
-
Homo sapiens
0.001
-
3-hydroxypyridine-2-carbonyl-glycine
-
Homo sapiens
0.002
-
3-hydroxypyridine-2-carbonyl-glycine
-
Homo sapiens
0.007
-
Pyridine-2,4-dicarboxylate
-
Homo sapiens
0.008
-
Pyridine-2,4-dicarboxylate
-
Homo sapiens
0.008
-
oxalglycine
-
Homo sapiens
0.01
-
3-carboxy-4-oxo-3,4-dihydro-1,10-phenanthroline
-
Homo sapiens
0.01
-
oxalglycine
-
Homo sapiens
0.015
-
3-hydroxypyridine-2-carbonyl-glycine
-
Homo sapiens
0.03
-
3-carboxy-4-oxo-3,4-dihydro-1,10-phenanthroline
-
Homo sapiens
0.04
-
Pyridine-2,4-dicarboxylate
-
Homo sapiens
0.05
-
oxalglycine
-
Homo sapiens