Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ascorbate | required for activity | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in Sf9 insect cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
R367K | no activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-carboxy-4-oxo-3,4-dihydro-1,10-phenanthroline | - |
Homo sapiens | |
3-hydroxypyridine-2-carbonyl-glycine | - |
Homo sapiens | |
N-[(6-chloro-3-hydroxyquinolin-2-yl)carbonyl]glycine | - |
Homo sapiens | |
oxalglycine | - |
Homo sapiens | |
Pyridine-2,4-dicarboxylate | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.006 | - |
DLDLEMLAPYIPMDDDFQLRSFDQ | - |
Homo sapiens | |
0.007 | - |
DLEMLAPYIPMDDDFQL | - |
Homo sapiens | |
0.007 | - |
DLDLEMLAPYIPMDDDFQL | - |
Homo sapiens | |
0.007 | - |
EMLAPYIPMDDDFQL | - |
Homo sapiens | |
0.007 | - |
DLDLEMLAPYIPMDDDF | - |
Homo sapiens | |
0.008 | - |
DLDLEMLAPYIPMDDDFQL | - |
Homo sapiens | |
0.008 | - |
DLDLEMLAPYIPMDDDFQLRSFDQ | - |
Homo sapiens | |
0.009 | - |
DLDLEMLAPYIPMDD | - |
Homo sapiens | |
0.01 | - |
DLDLEMLAPAIPMDDDFQL | C-terminal hydroxylation site of HIF-1alpha | Homo sapiens | |
0.014 | - |
DLEMLAPYIPMDDDFQL | - |
Homo sapiens | |
0.015 | - |
LAPYIPMDDDFQL | - |
Homo sapiens | |
0.02 | - |
DLDLEMLAPAIPMDDDFQL | C-terminal hydroxylation site of HIF-1alpha | Homo sapiens | |
0.02 | - |
DLDLEMLAPGIPMDDDFQL | C-terminal hydroxylation site of HIF-1alpha | Homo sapiens | |
0.03 | - |
DLDLEMLAPYIPMD | - |
Homo sapiens | |
0.035 | - |
EMLAPYIPMDDDFQL | - |
Homo sapiens | |
0.05 | - |
DLDLEMLAPYIPMDDDF | - |
Homo sapiens | |
0.05 | - |
DLDLEMLAPAIPMDDDFQLRSFDQ | - |
Homo sapiens | |
0.055 | - |
2-oxoglutarate | - |
Homo sapiens | |
0.06 | - |
2-oxoglutarate | - |
Homo sapiens | |
0.06 | - |
DLDLEMLAPYIPMDD | - |
Homo sapiens | |
0.07 | - |
DLDLEMLAPYIPMDDDF | - |
Homo sapiens | |
0.08 | - |
EMLAPYIPMDDDFQL | - |
Homo sapiens | |
0.1 | - |
DLDLEMLAPYIPMDD | - |
Homo sapiens | |
0.1 | - |
DLDLEMLAPYIPMD | - |
Homo sapiens | |
0.13 | - |
DALTLLAPAAGDTIISLFG | N-terminal hydroxylation site of HIF-1alpha | Homo sapiens | |
0.14 | - |
O2 | - |
Homo sapiens | |
0.14 | - |
ascorbate | - |
Homo sapiens | |
0.17 | - |
ascorbate | - |
Homo sapiens | |
0.18 | - |
ascorbate | - |
Homo sapiens | |
0.23 | - |
O2 | - |
Homo sapiens | |
0.38 | - |
DALTLLAPAAGDTIISLFG | N-terminal hydroxylation site of HIF-1alpha | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | required for activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxia-inducible factor L-proline + 2-oxoglutarate + O2 | Homo sapiens | - |
hypoxia inducible factor trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96KS0 | - |
- |
Homo sapiens | Q9GZT9 | - |
- |
Homo sapiens | Q9H6Z9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
skeletal muscle | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxoglutarate + O2 + ascorbate | - |
Homo sapiens | succinate + dehydroascorbate + CO2 + H2O | - |
? | |
DALTLLAPAAGDTIISLFG + 2-oxoglutarate + O2 | - |
Homo sapiens | DALTLLA-((4R)-4-hydroxy-L-proline)-AAGDTIISLFG + succinate + CO2 | - |
? | |
DLDLEMLAPAIPMDDDFQL + 2-oxoglutarate + O2 | - |
Homo sapiens | DLDLEMLA-((4R)-4-hydroxy-L-proline)-AIPMDDDFQL + succinate + CO2 | - |
? | |
DLDLEMLAPAIPMDDDFQLRSFDQ + 2-oxoglutarate + O2 | - |
Homo sapiens | DLDLEMLAPAIPMDDDFQLRSFDQ trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
DLDLEMLAPGIPMDDDFQL + 2-oxoglutarate + O2 | - |
Homo sapiens | DLDLEMLAPGIPMDDDFQL trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
DLDLEMLAPYIPMD + 2-oxoglutarate + O2 | - |
Homo sapiens | DLDLEMLAPYIPMD trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
DLDLEMLAPYIPMDD + 2-oxoglutarate + O2 | - |
Homo sapiens | DLDLEMLAPYIPMDD trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
DLDLEMLAPYIPMDDDF + 2-oxoglutarate + O2 | - |
Homo sapiens | DLDLEMLAPYIPMDDDF trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
DLDLEMLAPYIPMDDDFQL + 2-oxoglutarate + O2 | - |
Homo sapiens | DLDLEMLAPYIPMDDDFQL trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
DLDLEMLAPYIPMDDDFQLRSFDQ + 2-oxoglutarate + O2 | - |
Homo sapiens | DLDLEMLAPYIPMDDDFQLRSFDQ trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
DLEMLAPYIPMDDDFQL + 2-oxoglutarate + O2 | - |
Homo sapiens | DLEMLA-((4R)-4-hydroxy-L-proline)-YIPMDDDFQL + succinate + CO2 | - |
? | |
EMLAPYIPMDDDFQL + 2-oxoglutarate + O2 | - |
Homo sapiens | EMLAPYIPMDDDFQL trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
hypoxia-inducible factor L-proline + 2-oxoglutarate + O2 | - |
Homo sapiens | hypoxia inducible factor trans-4-hydroxy-L-proline + succinate + CO2 | - |
? | |
LAPYIPMDDDFQL + 2-oxoglutarate + O2 | - |
Homo sapiens | LAPYIPMDDDFQL trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HIF-P4H-1 | - |
Homo sapiens |
HIF-P4H-2 | - |
Homo sapiens |
HIF-P4H-3 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | - |
N-[(6-chloro-3-hydroxyquinolin-2-yl)carbonyl]glycine | - |
Homo sapiens | |
0.0008 | - |
N-[(6-chloro-3-hydroxyquinolin-2-yl)carbonyl]glycine | - |
Homo sapiens | |
0.001 | - |
3-hydroxypyridine-2-carbonyl-glycine | - |
Homo sapiens | |
0.002 | - |
3-hydroxypyridine-2-carbonyl-glycine | - |
Homo sapiens | |
0.007 | - |
Pyridine-2,4-dicarboxylate | - |
Homo sapiens | |
0.008 | - |
Pyridine-2,4-dicarboxylate | - |
Homo sapiens | |
0.008 | - |
oxalglycine | - |
Homo sapiens | |
0.01 | - |
3-carboxy-4-oxo-3,4-dihydro-1,10-phenanthroline | - |
Homo sapiens | |
0.01 | - |
oxalglycine | - |
Homo sapiens | |
0.015 | - |
3-hydroxypyridine-2-carbonyl-glycine | - |
Homo sapiens | |
0.03 | - |
3-carboxy-4-oxo-3,4-dihydro-1,10-phenanthroline | - |
Homo sapiens | |
0.04 | - |
Pyridine-2,4-dicarboxylate | - |
Homo sapiens | |
0.05 | - |
oxalglycine | - |
Homo sapiens |