KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.58 | - |
poly(ethylene glycol)-Gly-L-Tyr-L-Pro-Gly-OCH2CH2OH | 30°C, pH 7.8 | Homo sapiens | |
1.6 | - |
poly(ethylene glycol)-Gly-L-Tyr-L-(2S,4S)-4-fluoroproline-Gly-OCH2CH2OH | 30°C, pH 7.8 | Homo sapiens | |
6.4 | - |
poly(ethylene glycol)-Gly-L-Tyr-(2S)-4-thiaproline-Gly-OCH2CH2OH | 30°C, pH 7.8 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | iron(IV)-oxo species in the active site | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform P4H | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
poly(ethylene glycol)-Gly-L-Tyr-(2S)-4-thiaproline-Gly-OCH2CH2OH + 2-oxoglutarate + O2 | 6% of the activity with L-prolyl peptide substrate | Homo sapiens | poly(ethylene glycol)-Gly-L-Tyr-L-(2S,4R)-thiaoxoproline-Gly-OCH2CH2OH + ? + CO2 | - |
? | |
poly(ethylene glycol)-Gly-L-Tyr-L-(2S,4S)-4-fluoroproline-Gly-OCH2CH2OH + 2-oxoglutarate + O2 | 26% of the activity with L-prolyl peptide substrate | Homo sapiens | poly(ethylene glycol)-Gly-L-Tyr-L-(2S)-4-oxoproline-Gly-OCH2CH2OH + ? + CO2 | - |
? | |
poly(ethylene glycol)-Gly-L-Tyr-L-Pro-Gly-OCH2CH2OH + 2-oxoglutarate + O2 | - |
Homo sapiens | poly(ethylene glycol)-Gly-L-Tyr-L-(2S,4R)-4-hydroxy-Pro-Gly-OCH2CH2OH + succinate + CO2 | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4.2 | - |
poly(ethylene glycol)-Gly-L-Tyr-L-(2S,4S)-4-fluoroproline-Gly-OCH2CH2OH | 30°C, pH 7.8 | Homo sapiens | |
6 | - |
poly(ethylene glycol)-Gly-L-Tyr-L-Pro-Gly-OCH2CH2OH | 30°C, pH 7.8 | Homo sapiens | |
7.8 | - |
poly(ethylene glycol)-Gly-L-Tyr-(2S)-4-thiaproline-Gly-OCH2CH2OH | 30°C, pH 7.8 | Homo sapiens |