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Literature summary for 1.14.11.2 extracted from

  • Choi, H.J.; Soh, Y.
    An assay method for screening inhibitors of prolyl 4-hydroxylase in immortalized rat hepatic stellate HSC-T6 cells (2007), J. Appl. Pharmacol., 15, 261-265.
No PubMed abstract available

Application

Application Comment Organism
analysis assay method for screening the inhibitors of prolyl 4-hydroxylase to treat fibrosis. The assay uses rat hepatic stellate HSC-6 cells and cobalt chloride as a substitue for a hypoxic condition, the procedure takes three days after treatment with agents Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
HOE077 decrease in enzyme activity by 15% Rattus norvegicus
rosiglitazone decrease in enzyme activity by 32.3% Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
HSC-T6 cell treatment with ascorbate in a hypoxic condition for 24 h results in the maximal increase of hydroxyproline by 1.8-fold. The presence of cobalt chloride can substitute for hypoxic condition Rattus norvegicus
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