Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.2 extracted from

  • Vasta, J.D.; Choudhary, A.; Jensen, K.H.; McGrath, N.A.; Raines, R.T.
    Prolyl 4-hydroxylase substrate isosteres in which an (E)- or (Z)-alkene replaces the prolyl peptide bond (2017), Biochemistry, 56, 219-227 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.2

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens
expression in Escherichia coli Chlamydomonas reinhardtii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
-
 Homo sapiens
29000
-
-
 Chlamydomonas reinhardtii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2 Homo sapiens
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2 Chlamydomonas reinhardtii
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Chlamydomonas reinhardtii A8IDI8
-
-
Homo sapiens P13674 P4H alpha 1 subunit
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens
-
 Chlamydomonas reinhardtii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2
-
 Homo sapiens procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2
-
 Chlamydomonas reinhardtii procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2 the enzyme preferentially recognizes the cis conformation of the prolyl peptide bond Homo sapiens procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2 the enzyme preferentially recognizes the cis conformation of the prolyl peptide bond Chlamydomonas reinhardtii procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 29000 Homo sapiens
monomer 1 * 29000 Chlamydomonas reinhardtii

Synonyms

Synonyms Comment Organism
collagen prolyl 4-hydroxylase
-
 Homo sapiens
collagen prolyl 4-hydroxylase
-
 Chlamydomonas reinhardtii
CP4H1
-
 Homo sapiens
CrP4H-1
-
 Chlamydomonas reinhardtii

General Information

General Information Comment Organism
physiological function the enzyme catalyze a prevalent posttranslational modification, the hydroxylation of (2S)-proline residues in protocollagen strands. The ensuing (2S,4R)-4-hydroxyproline residues are necessary for the conformational stability of the collagen triple helix Homo sapiens
physiological function the enzyme catalyze a prevalent posttranslational modification, the hydroxylation of (2S)-proline residues in protocollagen strands. The ensuing (2S,4R)-4-hydroxyproline residues are necessary for the conformational stability of the collagen triple helix Chlamydomonas reinhardtii