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Literature summary for 1.14.11.27 extracted from

  • He, J.; Nguyen, A.T.; Zhang, Y.
    KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia (2011), Blood, 117, 3869-3880.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information Kdm2b/Jhmd1b is required for Hoxa9/Meis1-induced leukemic transformation in vitro Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 Homo sapiens KDM2b/JHDM1b is an H3K36me2-specific demethylase histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukemia cell high expression level of KDM2b/JHDM1b Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
-
Homo sapiens histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
?
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 KDM2b/JHDM1b is an H3K36me2-specific demethylase Homo sapiens histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
?

Synonyms

Synonyms Comment Organism
H3K36me2-specific demethylase
-
Homo sapiens
histone H3 lysine 36 dimethyl–specific demethylase
-
Homo sapiens
KDM2b/JHDM1b
-
Homo sapiens

General Information

General Information Comment Organism
malfunction depletion of Kdm2b/Jhdm1b in hematopoietic progenitors significantly impairs Hoxa9/Meis1-induced leukemic transformation. In leukemic stem cells, knockdown of Kdm2b/Jhdm1b impairs their self-renewing capability in vitro and in vivo Homo sapiens
additional information ectopic expression of Kdm2b/Jhdm1b is sufficient to transform hematopoietic progenitors Homo sapiens
physiological function Kdm2b/Jhdm1b functions as an oncogene and plays a critical role in leukemia development and maintenance, KDM2b/JHDM1b is required for initiation and maintenance of acute myeloid leukemia. Functions of Kdm2b/Jhdm1b are mediated by its silencing of p15Ink4b expression through active demethylation of histone H3-N6,N6-dimethyl-L-lysine. Kdm2b/Jhdm1b directly regulates p15Ink4b expression in leukemic cells Homo sapiens