Protein Variants | Comment | Organism |
---|---|---|
additional information | Kdm2b/Jhmd1b is required for Hoxa9/Meis1-induced leukemic transformation in vitro | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 | Homo sapiens | KDM2b/JHDM1b is an H3K36me2-specific demethylase | histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leukemia cell | high expression level of KDM2b/JHDM1b | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 | - |
Homo sapiens | histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? | |
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 | KDM2b/JHDM1b is an H3K36me2-specific demethylase | Homo sapiens | histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
H3K36me2-specific demethylase | - |
Homo sapiens |
histone H3 lysine 36 dimethylspecific demethylase | - |
Homo sapiens |
KDM2b/JHDM1b | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | depletion of Kdm2b/Jhdm1b in hematopoietic progenitors significantly impairs Hoxa9/Meis1-induced leukemic transformation. In leukemic stem cells, knockdown of Kdm2b/Jhdm1b impairs their self-renewing capability in vitro and in vivo | Homo sapiens |
additional information | ectopic expression of Kdm2b/Jhdm1b is sufficient to transform hematopoietic progenitors | Homo sapiens |
physiological function | Kdm2b/Jhdm1b functions as an oncogene and plays a critical role in leukemia development and maintenance, KDM2b/JHDM1b is required for initiation and maintenance of acute myeloid leukemia. Functions of Kdm2b/Jhdm1b are mediated by its silencing of p15Ink4b expression through active demethylation of histone H3-N6,N6-dimethyl-L-lysine. Kdm2b/Jhdm1b directly regulates p15Ink4b expression in leukemic cells | Homo sapiens |