BRENDA - Enzyme Database show
show all sequences of 1.14.11.27

KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors

Black, J.C.; Manning, A.L.; Van Rechem, C.; Kim, J.; Ladd, B.; Cho, J.; Pineda, C.M.; Murphy, N.; Daniels, D.L.; Montagna, C.; Lewis, P.W.; Glass, K.; Allis, C.D.; Dyson, N.J.; Getz, G.; Whetstine, J.R.; Cell 154, 541-555 (2013)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
enzyme overexpression in HEK-293T cells, phenotype,, overview
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
H188A
inactive mutant
Homo sapiens
additional information
KDM4A/JMJD2A overexpression leads to localized copy gain of 1q12, 1q21, and Xq13.1 without global chromosome instability
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
-
Homo sapiens
5634
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Homo sapiens
bifunctional H3K9/36me3 lysine demethylase KDM4A/JMJD2A acting on Lys 9 and Lys36 of histone 3
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
HEK-293T cell
-
Homo sapiens
-
hTERT-RPE1 cell
-
Homo sapiens
-
additional information
KDM4A is amplified and overexpressed in several tumor types
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
bifunctional H3K9/36me3 lysine demethylase KDM4A/JMJD2A acting on Lys 9 and Lys36 of histone 3
724709
Homo sapiens
?
-
-
-
-
Cloned(Commentary) (protein specific)
Commentary
Organism
enzyme overexpression in HEK-293T cells, phenotype,, overview
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
H188A
inactive mutant
Homo sapiens
additional information
KDM4A/JMJD2A overexpression leads to localized copy gain of 1q12, 1q21, and Xq13.1 without global chromosome instability
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
nucleus
-
Homo sapiens
5634
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Homo sapiens
bifunctional H3K9/36me3 lysine demethylase KDM4A/JMJD2A acting on Lys 9 and Lys36 of histone 3
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
HEK-293T cell
-
Homo sapiens
-
hTERT-RPE1 cell
-
Homo sapiens
-
additional information
KDM4A is amplified and overexpressed in several tumor types
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
bifunctional H3K9/36me3 lysine demethylase KDM4A/JMJD2A acting on Lys 9 and Lys36 of histone 3
724709
Homo sapiens
?
-
-
-
-
General Information
General Information
Commentary
Organism
evolution
KDM4A belongs to the KDM4 family
Homo sapiens
physiological function
H3K9me3 demethylase KDM4A/JMJD2A is able to increase accessibility and alter the replication timing at specific heterochromatic regions. KDM4A overexpression promotes copy gain of 1q12, 1q21, and Xq13.1 in cancer cells and results in site-specific copy gain of regions amplified in human tumors. These copy gains are not stably inherited but are generated transiently in each subsequent S phase and cleared by late G2. KDM4A is the only KDM4 family member that generated the gains in a catalytically dependent manner, copy gains are antagonized by coexpression of Suv39h1/KMT1A or HP1gamma, and promoted by H3K9 or H3K36 methylation interference. KDM4A associates with replication machinery and promotes rereplication of 1q12. KDM4A overexpression promotes chromatin state Changes and Recruitment of replication machinery
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
evolution
KDM4A belongs to the KDM4 family
Homo sapiens
physiological function
H3K9me3 demethylase KDM4A/JMJD2A is able to increase accessibility and alter the replication timing at specific heterochromatic regions. KDM4A overexpression promotes copy gain of 1q12, 1q21, and Xq13.1 in cancer cells and results in site-specific copy gain of regions amplified in human tumors. These copy gains are not stably inherited but are generated transiently in each subsequent S phase and cleared by late G2. KDM4A is the only KDM4 family member that generated the gains in a catalytically dependent manner, copy gains are antagonized by coexpression of Suv39h1/KMT1A or HP1gamma, and promoted by H3K9 or H3K36 methylation interference. KDM4A associates with replication machinery and promotes rereplication of 1q12. KDM4A overexpression promotes chromatin state Changes and Recruitment of replication machinery
Homo sapiens
Other publictions for EC 1.14.11.27
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
743916
Hancock
The activity of JmjC histone ...
Homo sapiens
ACS Chem. Biol.
12
1011-1019
2017
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2
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745949
An
HistoneH3 demethylase JMJD2A ...
Homo sapiens
Oncotarget
8
49093-49109
2017
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2
2
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744722
Morera
4-biphenylalanine- and 3-phen ...
Homo sapiens
ChemMedChem
11
2063-2083
2016
1
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1
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33
1
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33
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1
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2
2
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744785
Pedersen
Continual removal of H3K9 pro ...
Mus musculus, Mus musculus C57BL/6
EMBO J.
35
1550-1564
2016
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1
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1
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8
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3
6
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745803
Gacek-Matthews
KdmA, a histone H3 demethylas ...
Aspergillus nidulans, Aspergillus nidulans WIM126
Mol. Microbiol.
96
839-860
2015
-
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1
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1
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1
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4
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1
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3
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744589
Ryu
Yeast histone H3 lysine 4 dem ...
Saccharomyces cerevisiae
BMC Biol.
12
75
2014
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1
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1
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7
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7
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3
9
-
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-
745919
Kupershmit
KDM4C (GASC1) lysine demethyl ...
Homo sapiens
Nucleic Acids Res.
42
6168-6182
2014
-
-
1
-
3
-
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2
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1
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16
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5
4
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3
12
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724709
Black
KDM4A lysine demethylase induc ...
Homo sapiens
Cell
154
541-555
2013
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1
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2
2
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724813
Crona
Gene regulation by the lysine ...
Drosophila melanogaster
Dev. Biol.
373
453-463
2013
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1
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2
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1
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2
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3
3
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724815
Ishimura
Jmjd5, an H3K36me2 histone dem ...
Mus musculus
Development
139
749-759
2012
-
-
1
-
2
-
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1
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3
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1
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4
4
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725960
Del Rizzo
Crystal structure and function ...
Homo sapiens
Mol. Cell. Biol.
32
4044-4052
2012
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1
1
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1
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1
-
-
-
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3
3
-
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726260
Pan
The histone demethylase Jhdm1a ...
Homo sapiens, Mus musculus, Mus musculus C57/BL6J
PLoS Genet.
8
e1002761
2012
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2
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3
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6
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62
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10
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10
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5
5
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726301
Lin
HP1a targets the Drosophila KD ...
Drosophila melanogaster
PLoS ONE
7
e39758
2012
1
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1
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2
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1
1
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712996
Peng
Molecular characterization of ...
Sus scrofa
Mol. Biol. Rep.
38
4697-4704
2011
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1
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724651
He
KDM2b/JHDM1b, an H3K36me2-spec ...
Homo sapiens
Blood
117
3869-3880
2011
-
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1
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3
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725450
Hillringhaus
Structural and evolutionary ba ...
Homo sapiens
J. Biol. Chem.
286
41616-41625
2011
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12
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12
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6
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726071
Liang
The histone H3K36 demethylase ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742
Nucleic Acids Res.
39
4151-4165
2011
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1
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1
1
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24
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1
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4
4
2
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726379
Fnu
Methylation of histone H3 lysi ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
108
540-545
2011
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1
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711153
Chang
Crystal structure of the catal ...
Saccharomyces cerevisiae
Biochem. J.
433
295-302
2010
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1
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7
1
1
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1
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1
1
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711823
Strobl-Mazzulla
Histone demethylase JmjD2A reg ...
Gallus gallus
Dev. Cell
19
460-468
2010
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1
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1
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2
2
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696434
Marmorstein
Histone modifying enzymes: str ...
Homo sapiens
Biochim. Biophys. Acta
1789
58-68
2009
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1
1
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1
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5
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697140
Li
Alterations of histone modific ...
Homo sapiens
Carcinogenesis
30
1243-1251
2009
1
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1
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Ng
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