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Literature summary for 1.14.11.27 extracted from

  • Fnu, S.; Williamson, E.; De Haro, L.; Brenneman, M.; Wray, J.; Shaheen, M.; Radhakrishnan, K.; Lee, S.; Nickoloff, J.; Hromas, R.
    Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining (2011), Proc. Natl. Acad. Sci. USA, 108, 540-545.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 Homo sapiens
-
 histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HT-1080 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2
-
 Homo sapiens histone H3-N6-methyl-L-lysine36 + succinate + formaldehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
H3K36me2 demethylase
-
 Homo sapiens
JHDM1A
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function demethylation of H3K36 reduces DSB repair. Expression of JHDM1a decreases the association of early NHEJ repair components with an induced DSB and decreased DSB repair Homo sapiens