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Literature summary for 1.14.11.27 extracted from

  • Turberfield, A.H.; Kondo, T.; Nakayama, M.; Koseki, Y.; King, H.W.; Koseki, H.; Klose, R.J.
    KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity (2019), Nucleic Acids Res., 47, 9005-9023 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus P59997
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Mus musculus Q6P1G2
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Synonyms

Synonyms Comment Organism
Kdm2a
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 Mus musculus
KDM2B
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 Mus musculus

General Information

General Information Comment Organism
physiological function histone H3 lysine 36 demethylase activity of the CpG islands (CGI) binding KDM2 proteins contributes only modestly to the H3K36me2-depleted state at CGI-associated gene promoters and is dispensable for normal gene expression. KDM2 proteins play a widespread and demethylase-independent role in constraining gene expression from CGI-associated gene promoters. KDM2 proteins shape RNA Polymerase II occupancy but not chromatin accessibility at CGI-associated promoters Mus musculus