BRENDA - Enzyme Database show
show all sequences of 1.14.11.29

A conserved family of prolyl-4-hydroxylases that modify HIF

Bruick, R.K.; McKnight, S.L.; Science 294, 1337-1340 (2001)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in Escherichia coli
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
D137A
mutation eliminates prolyl hydroxylase activity of HPH-1
Homo sapiens
H135A
mutation eliminates prolyl hydroxylase activity of HPH-1
Homo sapiens
H196A
mutation eliminates prolyl hydroxylase activity of HPH-1
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
oxygen
the transiently overexpressed HPH-1 enzyme is inhibited by a low-oxygen environment
Homo sapiens
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Fe2+
the enzyme contains Fe2+; the enzyme contains Fe2+; the enzyme contains Fe2+
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
Homo sapiens
mammalian cells respond to changes in oxygen availability through a conserved pathway that is regulated by the hypoxia-inducible factor (HIF). The alpha subunit of the hypoxia-inducible factor is targeted for degradation under normoxic conditions by a ubiquitin-ligase complex that recognizes a hydroxylated proline residue in hypoxia-inducible factor. HIF prolyl hydroxylase is responsible for this posttranslational modification
hypoxia-inducible factor-(4R)-4-hydroxy-L-proline + succinate + CO2
-
-
?
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
Homo sapiens
mammalian cells respond to changes in oxygen availability through a conserved pathway that is regulated by the hypoxia-inducible factor (HIF). The alpha subunit of the hypoxia-inducible factor is targeted for degradation under normoxic conditions by a ubiquitin-ligase complex that recognizes a hydroxylated proline residue in hypoxia-inducible factor. HIF prolyl is responsible for this posttranslational modification
hypoxia-inducible factor-(4R)-4-hydroxy-L-proline + succinate + CO2
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Drosophila melanogaster
-
-
-
Homo sapiens
-
-
-
Homo sapiens
Q96KS0
HPH-3
-
Homo sapiens
Q9GZT9
HPH-2
-
Purification (Commentary)
Commentary
Organism
-
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
mammalian cells respond to changes in oxygen availability through a conserved pathway that is regulated by the hypoxia-inducible factor (HIF). The alpha subunit of the hypoxia-inducible factor is targeted for degradation under normoxic conditions by a ubiquitin-ligase complex that recognizes a hydroxylated proline residue in hypoxia-inducible factor. HIF prolyl hydroxylase is responsible for this posttranslational modification
701219
Homo sapiens
hypoxia-inducible factor-(4R)-4-hydroxy-L-proline + succinate + CO2
-
-
-
?
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
mammalian cells respond to changes in oxygen availability through a conserved pathway that is regulated by the hypoxia-inducible factor (HIF). The alpha subunit of the hypoxia-inducible factor is targeted for degradation under normoxic conditions by a ubiquitin-ligase complex that recognizes a hydroxylated proline residue in hypoxia-inducible factor. HIF prolyl is responsible for this posttranslational modification
701219
Homo sapiens
hypoxia-inducible factor-(4R)-4-hydroxy-L-proline + succinate + CO2
-
-
-
?
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
target proline residue: Pro564 in human HIF-alpha. A control peptide in which the target proline residue is replaced by alanine is not modified
701219
Homo sapiens
hypoxia-inducible factor-(4R)-4-hydroxy-L-proline + succinate + CO2
-
-
-
?
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
target proline residue: Pro564 in human HIF-alpha. A control peptide in which the target proline residue is replaced by alanine is not modified. The endogenous HIF prolyl hydroxylase, HPH-1 generates by in vitro transcription/translation does not modify peptides containing the L562A, A563G, or Y565A mutations. However, a peptide containing the Pro567 to Gly mutation is an equal, if not better, substrate for the human HPH enzymes
701219
Homo sapiens
hypoxia-inducible factor-(4R)-4-hydroxy-L-proline + succinate + CO2
-
-
-
?
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
target proline residue: Pro564 in human HIF-alpha. A control peptide in which the target proline residue is replaced by alanine is not modified. The recombinant HPH-2 purified from Escherichia coli does not modify peptides containing the L562A, A563G, or Y565A mutations. However, a peptide containing the Pro567 to Gly mutation is an equal, if not better, substrate for the human HPH enzymes
701219
Homo sapiens
hypoxia-inducible factor-(4R)-4-hydroxy-L-proline + succinate + CO2
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
expression in Escherichia coli
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
D137A
mutation eliminates prolyl hydroxylase activity of HPH-1
Homo sapiens
H135A
mutation eliminates prolyl hydroxylase activity of HPH-1
Homo sapiens
H196A
mutation eliminates prolyl hydroxylase activity of HPH-1
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
oxygen
the transiently overexpressed HPH-1 enzyme is inhibited by a low-oxygen environment
Homo sapiens
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Fe2+
the enzyme contains Fe2+
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
Homo sapiens
mammalian cells respond to changes in oxygen availability through a conserved pathway that is regulated by the hypoxia-inducible factor (HIF). The alpha subunit of the hypoxia-inducible factor is targeted for degradation under normoxic conditions by a ubiquitin-ligase complex that recognizes a hydroxylated proline residue in hypoxia-inducible factor. HIF prolyl hydroxylase is responsible for this posttranslational modification
hypoxia-inducible factor-(4R)-4-hydroxy-L-proline + succinate + CO2
-
-
?
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
Homo sapiens
mammalian cells respond to changes in oxygen availability through a conserved pathway that is regulated by the hypoxia-inducible factor (HIF). The alpha subunit of the hypoxia-inducible factor is targeted for degradation under normoxic conditions by a ubiquitin-ligase complex that recognizes a hydroxylated proline residue in hypoxia-inducible factor. HIF prolyl is responsible for this posttranslational modification
hypoxia-inducible factor-(4R)-4-hydroxy-L-proline + succinate + CO2
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
mammalian cells respond to changes in oxygen availability through a conserved pathway that is regulated by the hypoxia-inducible factor (HIF). The alpha subunit of the hypoxia-inducible factor is targeted for degradation under normoxic conditions by a ubiquitin-ligase complex that recognizes a hydroxylated proline residue in hypoxia-inducible factor. HIF prolyl hydroxylase is responsible for this posttranslational modification
701219
Homo sapiens
hypoxia-inducible factor-(4R)-4-hydroxy-L-proline + succinate + CO2
-
-
-
?
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
mammalian cells respond to changes in oxygen availability through a conserved pathway that is regulated by the hypoxia-inducible factor (HIF). The alpha subunit of the hypoxia-inducible factor is targeted for degradation under normoxic conditions by a ubiquitin-ligase complex that recognizes a hydroxylated proline residue in hypoxia-inducible factor. HIF prolyl is responsible for this posttranslational modification
701219
Homo sapiens
hypoxia-inducible factor-(4R)-4-hydroxy-L-proline + succinate + CO2
-
-
-
?
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
target proline residue: Pro564 in human HIF-alpha. A control peptide in which the target proline residue is replaced by alanine is not modified
701219
Homo sapiens
hypoxia-inducible factor-(4R)-4-hydroxy-L-proline + succinate + CO2
-
-
-
?
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
target proline residue: Pro564 in human HIF-alpha. A control peptide in which the target proline residue is replaced by alanine is not modified. The endogenous HIF prolyl hydroxylase, HPH-1 generates by in vitro transcription/translation does not modify peptides containing the L562A, A563G, or Y565A mutations. However, a peptide containing the Pro567 to Gly mutation is an equal, if not better, substrate for the human HPH enzymes
701219
Homo sapiens
hypoxia-inducible factor-(4R)-4-hydroxy-L-proline + succinate + CO2
-
-
-
?
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
target proline residue: Pro564 in human HIF-alpha. A control peptide in which the target proline residue is replaced by alanine is not modified. The recombinant HPH-2 purified from Escherichia coli does not modify peptides containing the L562A, A563G, or Y565A mutations. However, a peptide containing the Pro567 to Gly mutation is an equal, if not better, substrate for the human HPH enzymes
701219
Homo sapiens
hypoxia-inducible factor-(4R)-4-hydroxy-L-proline + succinate + CO2
-
-
-
?
General Information
General Information
Commentary
Organism
physiological function
in cultured mammalian cells, inappropriate accumulation of hypoxia-inducible factor caused by forced expression of the hypoxia-inducible factor-1alpha subunit under normoxic conditions is attenuated by coexpression of HIF prolyl hydroxylase. Suppression of HIF prolyl hydroxylase in cultured Drosophila melanogaster cells by RNA interference results in elevated expression of a hypoxia-inducible gene (LDH, encoding lactate dehydrogenase) under normoxic conditions. HIF prolyl hydroxylase is an essential component of the pathway through which cells sense oxygen; in cultured mammalian cells, inappropriate accumulation of hypoxia-inducible factor caused by forced expression of the hypoxia-inducible factor-1alpha subunit under normoxic conditions is attenuated by coexpression of HIF prolyl hydroxylase. Suppression of HIF prolyl hydroxylase in cultured Drosophila melanogaster cells by RNA interference results in elevated expression of a hypoxia-inducible gene (LDH, encoding lactate dehydrogenase) under normoxic conditions. HIF prolyl hydroxylase is an essential component of the pathway through which cells sense oxygen; in cultured mammalian cells, inappropriate accumulation of hypoxia-inducible factor caused by forced expression of the hypoxia-inducible factor-1alpha subunit under normoxic conditions is attenuated by coexpression of HIF prolyl. Suppression of HIF prolyl in cultured Drosophila melanogaster cells by RNA interference results in elevated expression of a hypoxia-inducible gene (LDH, encoding lactate dehydrogenase) under normoxic conditions. HIF prolyl is an essential component of the pathway through which cells sense oxygen
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
physiological function
in cultured mammalian cells, inappropriate accumulation of hypoxia-inducible factor caused by forced expression of the hypoxia-inducible factor-1alpha subunit under normoxic conditions is attenuated by coexpression of HIF prolyl hydroxylase. Suppression of HIF prolyl hydroxylase in cultured Drosophila melanogaster cells by RNA interference results in elevated expression of a hypoxia-inducible gene (LDH, encoding lactate dehydrogenase) under normoxic conditions. HIF prolyl hydroxylase is an essential component of the pathway through which cells sense oxygen
Homo sapiens
physiological function
in cultured mammalian cells, inappropriate accumulation of hypoxia-inducible factor caused by forced expression of the hypoxia-inducible factor-1alpha subunit under normoxic conditions is attenuated by coexpression of HIF prolyl. Suppression of HIF prolyl in cultured Drosophila melanogaster cells by RNA interference results in elevated expression of a hypoxia-inducible gene (LDH, encoding lactate dehydrogenase) under normoxic conditions. HIF prolyl is an essential component of the pathway through which cells sense oxygen
Homo sapiens
Other publictions for EC 1.14.11.29
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741945
Osipyants
Enzyme–substrate reporters fo ...
Homo sapiens
Biochemistry
82
1207-1214
2017
-
-
-
-
-
-
4
-
-
-
-
3
-
3
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
12
-
-
-
-
-
3
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
742225
Miikkulainen
HIF prolyl hydroxylase PHD3 r ...
Homo sapiens
Cancer Metab.
5
5-5
2017
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
742585
Badawi
Relative contribution of prol ...
Homo sapiens
Front. Neurosci.
11
239
2017
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
743380
Kozlova
Hypoxia-inducible factor prol ...
Homo sapiens
Oncotarget
8
9885-9898
2017
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
741826
Chen
Alternative splicing transcri ...
Megalobrama amblycephala
Biochem. Biophys. Res. Commun.
469
737-742
2016
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
10
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
10
-
-
1
1
-
-
-
-
-
-
-
-
1
1
1
1
-
-
743284
Kapitsinou
The endothelial prolyl-4-hydr ...
Mus musculus
Mol. Cell. Biol.
36
1584-1594
2016
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
743285
Arsenault
The zinc finger of prolyl hyd ...
Mus musculus
Mol. Cell. Biol.
36
2328-2343
2016
-
-
-
-
-
-
-
-
-
1
-
1
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
741910
Pektas
Increased turnover at limitin ...
Homo sapiens
Biochemistry
54
2851-2857
2015
-
-
1
-
2
-
-
9
-
-
-
1
-
2
-
-
1
-
-
-
-
-
2
1
-
-
-
9
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
9
-
-
-
1
-
-
-
1
-
-
-
-
2
1
-
-
-
9
-
-
-
-
-
-
-
-
8
8
742307
Bishop
HIF hydroxylase pathways in c ...
Homo sapiens
Circ. Res.
117
65-79
2015
-
-
-
-
-
-
2
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
742656
Wang
Current advances in the novel ...
Caenorhabditis elegans, Drosophila melanogaster
Insect Mol. Biol.
24
634-648
2015
-
-
-
-
-
-
-
-
-
-
-
2
-
7
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
743203
Giannetto
Hypoxia-inducible factor alph ...
Mytilus galloprovincialis
Mar. Biotechnol.
17
768-781
2015
-
-
-
-
-
-
-
-
-
-
-
1
-
7
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
743581
Chan
Potent and selective triazole ...
Homo sapiens, Mus musculus
PLoS ONE
10
e0132004
2015
-
-
-
2
-
-
16
-
-
-
-
-
-
6
-
-
-
-
-
7
-
-
6
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
3
-
-
6
37
-
-
-
-
-
-
-
-
-
-
-
21
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
744664
Sun
Prolyl-4-hydroxylase 2 potent ...
Homo sapiens
Cell. Physiol. Biochem.
37
2257-2264
2015
-
1
1
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
745336
Li
Prolyl-4-hydroxylase domain p ...
Homo sapiens, Rattus norvegicus
J. Biol. Chem.
290
7195-7207
2015
-
1
2
-
1
-
-
-
-
-
-
2
-
2
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
4
4
-
-
-
741852
Tarhonskaya
Investigating the contributio ...
Homo sapiens
Biochem. J.
463
363-372
2014
-
-
-
-
2
-
-
-
-
1
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
742048
Fan
The hypoxia-inducible factor ...
Homo sapiens
BioMed Res. Int.
2014
239356
2014
-
-
-
-
-
-
17
-
-
-
-
2
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
17
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
742072
Hong
Discovery of novel 2-[2-(3-hy ...
Homo sapiens
Bioorg. Med. Chem. Lett.
24
3142-3145
2014
-
-
-
-
-
-
33
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
24
-
-
-
-
-
-
-
24
33
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
744649
Sun
Prolyl-4-hydroxylase 2 enhanc ...
Homo sapiens
Cell Death Dis.
5
e1322
2014
-
1
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
745510
Taylor
A PHD in macrophage survival ...
Mus musculus
J. Leukoc. Biol.
96
365-375
2014
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
1
4
4
1
-
-
724696
Cavadas
Hypoxia-inducible factor (HIF) ...
Homo sapiens
Cell Commun. Signal.
11
42
2013
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
725596
Nguyen
A dynamic model of the hypoxia ...
Homo sapiens
J. Cell Sci.
126
1454-1463
2013
-
-
-
-
-
-
3
-
-
1
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
4
4
-
-
-
725653
Pektas
Substrate preference of the HI ...
Homo sapiens
J. Inorg. Biochem.
126
55-60
2013
1
-
1
-
-
-
-
4
-
1
-
2
-
1
-
-
1
-
-
1
-
-
3
-
1
-
-
4
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
4
-
1
-
2
-
-
-
1
-
1
-
-
3
-
1
-
-
4
1
-
-
-
-
1
1
-
4
4
724847
Masson
The FIH hydroxylase is a cellu ...
Homo sapiens
EMBO Rep.
13
251-257
2012
1
-
-
-
-
-
1
-
-
1
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
725647
Flagg
Screening chelating inhibitors ...
Homo sapiens
J. Inorg. Biochem.
113
25-30
2012
1
1
1
-
-
-
12
1
-
1
-
1
-
2
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
10
1
1
1
-
-
-
-
10
12
-
1
-
1
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
726084
Cao
Evidence for inhibition of HIF ...
Homo sapiens
Org. Biomol. Chem.
10
3913-3923
2012
1
-
1
-
-
-
5
2
-
1
-
1
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
4
-
4
1
-
1
-
-
-
-
4
5
4
2
-
1
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724225
Pappalardi
Biochemical characterization o ...
Homo sapiens
Biochem. J.
436
363-369
2011
1
-
1
-
-
-
-
4
-
1
-
3
-
3
-
-
1
-
-
-
-
-
19
-
1
-
-
3
1
-
-
-
-
-
-
3
-
3
-
-
-
-
-
-
-
6
-
3
-
3
-
-
-
3
-
-
-
-
19
-
3
-
-
3
3
-
-
-
-
2
6
-
-
-
724523
Kwon
Inhibition of a prolyl hydroxy ...
Homo sapiens
Bioorg. Med. Chem. Lett.
21
4325-4328
2011
-
-
1
-
-
-
6
-
-
1
-
1
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
6
-
-
-
1
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
725644
Geng
Effects of polynitrogen compou ...
Homo sapiens
J. Inorg. Biochem.
105
391-399
2011
1
-
1
-
-
-
5
-
-
-
3
1
-
1
-
-
1
-
-
-
-
-
2
1
1
-
-
-
1
-
-
-
5
-
4
1
-
1
-
-
-
-
4
5
5
-
-
-
3
1
-
-
-
1
-
-
-
-
2
1
1
-
-
-
1
-
-
-
-
2
2
-
-
-
659235
Hirsila
Characterization of the human ...
Homo sapiens
J. Biol. Chem.
278
30772-30780
2003
1
-
1
-
1
-
5
37
-
-
-
3
-
3
-
-
1
-
-
8
-
-
48
-
1
-
-
-
1
-
-
-
14
-
-
3
-
3
-
-
1
-
-
15
18
48
-
-
-
3
-
-
-
2
-
16
-
-
48
-
3
-
-
-
3
-
-
-
-
-
-
-
-
-
701217
Ivan
HIF alpha targeted for VHL-med ...
Homo sapiens
Science
292
464-468
2001
-
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
701218
Jaakkola
Targeting of HIF-alpha to the ...
Homo sapiens
Science
292
468-472
2001
1
-
-
-
-
-
2
-
-
1
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
701219
Bruick
A conserved family of prolyl-4 ...
Drosophila melanogaster, Homo sapiens
Science
294
1337-1340
2001
-
-
1
-
3
-
1
-
-
1
-
3
-
5
-
-
1
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
3
-
-
1
-
-
-
3
-
3
-
-
-
3
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
1
3
-
-
-