BRENDA - Enzyme Database show
show all sequences of 1.14.11.29

HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma

Miikkulainen, P.; Hoegel, H.; Rantanen, K.; Suomi, T.; Kouvonen, P.; Elo, L.L.; Jaakkola, P.M.; Cancer Metab. 5, 5-5 (2017)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
Homo sapiens
-
hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q9H6Z9
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
786-O cell
-
Homo sapiens
-
clear cell renal cell carcinoma cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
-
742225
Homo sapiens
hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
Homo sapiens
-
hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
786-O cell
-
Homo sapiens
-
clear cell renal cell carcinoma cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
-
742225
Homo sapiens
hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2
-
-
-
?
General Information
General Information
Commentary
Organism
malfunction
isoform PHD3 silencing leads to downregulation of most glycolytic enzymes from glucose transport to lactate production supported by the reduction in extracellular acidification and lactate production and increase in cellular oxygen consumption rate
Homo sapiens
physiological function
isoform PHD3 is involved in the maintenance of key cellular functions including glycolysis and protein synthesis in clear cell renal cell carcinoma. The enzyme regulates ribosomal subunits and protein translation in clear cell renal cell carcinoma
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
malfunction
isoform PHD3 silencing leads to downregulation of most glycolytic enzymes from glucose transport to lactate production supported by the reduction in extracellular acidification and lactate production and increase in cellular oxygen consumption rate
Homo sapiens
physiological function
isoform PHD3 is involved in the maintenance of key cellular functions including glycolysis and protein synthesis in clear cell renal cell carcinoma. The enzyme regulates ribosomal subunits and protein translation in clear cell renal cell carcinoma
Homo sapiens
Other publictions for EC 1.14.11.29
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741945
Osipyants
Enzyme–substrate reporters ...
Homo sapiens
Biochemistry
82
1207-1214
2017
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742225
Miikkulainen
HIF prolyl hydroxylase PHD3 r ...
Homo sapiens
Cancer Metab.
5
5-5
2017
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742585
Badawi
Relative contribution of prol ...
Homo sapiens
Front. Neurosci.
11
239
2017
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743380
Kozlova
Hypoxia-inducible factor prol ...
Homo sapiens
Oncotarget
8
9885-9898
2017
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1
1
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2
2
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741826
Chen
Alternative splicing transcri ...
Megalobrama amblycephala
Biochem. Biophys. Res. Commun.
469
737-742
2016
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1
1
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1
1
1
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743284
Kapitsinou
The endothelial prolyl-4-hydr ...
Mus musculus
Mol. Cell. Biol.
36
1584-1594
2016
-
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1
1
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743285
Arsenault
The zinc finger of prolyl hyd ...
Mus musculus
Mol. Cell. Biol.
36
2328-2343
2016
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741910
Pektas
Increased turnover at limitin ...
Homo sapiens
Biochemistry
54
2851-2857
2015
-
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1
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2
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9
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1
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1
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9
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8
8
742307
Bishop
HIF hydroxylase pathways in c ...
Homo sapiens
Circ. Res.
117
65-79
2015
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742656
Wang
Current advances in the novel ...
Caenorhabditis elegans, Drosophila melanogaster
Insect Mol. Biol.
24
634-648
2015
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7
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2
2
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743203
Giannetto
Hypoxia-inducible factor alph ...
Mytilus galloprovincialis
Mar. Biotechnol.
17
768-781
2015
-
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1
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7
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743581
Chan
Potent and selective triazole ...
Homo sapiens, Mus musculus
PLoS ONE
10
e0132004
2015
-
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2
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16
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6
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7
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6
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6
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3
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6
37
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21
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6
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744664
Sun
Prolyl-4-hydroxylase 2 potent ...
Homo sapiens
Cell. Physiol. Biochem.
37
2257-2264
2015
-
1
1
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1
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1
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2
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2
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1
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1
1
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1
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2
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1
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3
3
-
-
-
745336
Li
Prolyl-4-hydroxylase domain p ...
Homo sapiens, Rattus norvegicus
J. Biol. Chem.
290
7195-7207
2015
-
1
2
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1
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2
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2
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4
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2
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2
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4
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2
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4
4
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741852
Tarhonskaya
Investigating the contributio ...
Homo sapiens
Biochem. J.
463
363-372
2014
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2
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1
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742048
Fan
The hypoxia-inducible factor ...
Homo sapiens
BioMed Res. Int.
2014
239356
2014
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17
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2
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1
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17
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742072
Hong
Discovery of novel 2-[2-(3-hy ...
Homo sapiens
Bioorg. Med. Chem. Lett.
24
3142-3145
2014
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33
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1
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1
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33
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744649
Sun
Prolyl-4-hydroxylase 2 enhanc ...
Homo sapiens
Cell Death Dis.
5
e1322
2014
-
1
1
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1
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1
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1
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4
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2
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745510
Taylor
A PHD in macrophage survival ...
Mus musculus
J. Leukoc. Biol.
96
365-375
2014
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724696
Cavadas
Hypoxia-inducible factor (HIF) ...
Homo sapiens
Cell Commun. Signal.
11
42
2013
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3
3
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725596
Nguyen
A dynamic model of the hypoxia ...
Homo sapiens
J. Cell Sci.
126
1454-1463
2013
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3
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1
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4
4
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725653
Pektas
Substrate preference of the HI ...
Homo sapiens
J. Inorg. Biochem.
126
55-60
2013
1
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1
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4
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1
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2
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1
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1
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1
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1
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4
4
724847
Masson
The FIH hydroxylase is a cellu ...
Homo sapiens
EMBO Rep.
13
251-257
2012
1
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1
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1
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2
2
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725647
Flagg
Screening chelating inhibitors ...
Homo sapiens
J. Inorg. Biochem.
113
25-30
2012
1
1
1
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12
1
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1
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1
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2
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2
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1
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1
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10
1
1
1
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10
12
-
1
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1
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1
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