Literature summary for 1.14.11.29 extracted from

Tong, J.; Yu, F.C.; Li, Y.; Wei, Q.; Li, C.; Zhen, P.; Zhang, G.
Prolyl 4-hydroxylase domain protein 3-inhibited smooth-muscle-cell dedifferentiation improves cardiac perivascular fibrosis induced by obstructive sleep apnea (2019), BioMed Res. Int., 2019, 9174218 .

Search for more literature for 1.14.11.29

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q91UZ4	C57BL/6 mice	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2	-	Mus musculus	hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2	-	?

Synonyms

Synonyms	Comment	Organism
PHD3	-	Mus musculus
prolyl 4-hydroxylase	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	the expression of prolyl 4-hydroxylase domain protein 3 (PHD3) increases under hypoxia. Fibrosis improves when PHD3 is overexpressed	up

General Information

General Information	Comment	Organism
drug target	prolyl 4-hydroxylase domain protein 3 (PHD3) overexpression has therapeutic potential in treatment of obstructive sleep apnea and intermittent hypoxia induced cardiovascular fibrosis	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)