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Literature summary for 1.14.11.30 extracted from

  • Sim, J.; Cowburn, A.S.; Palazon, A.; Madhu, B.; Tyrakis, P.A.; Macias, D.; Bargiela, D.M.; Pietsch, S.; Gralla, M.; Evans, C.E.; Kittipassorn, T.; Chey, Y.C.J.; Branco, C.M.; Rundqvist, H.; Peet, D.J.; Johnson, R.S.
    The factor inhibiting HIF asparaginyl hydroxylase regulates oxidative metabolism and accelerates metabolic adaptation to hypoxia (2018), Cell Metab., 27, 898-913.e7 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus Q8BLR9
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Source Tissue

Source Tissue Comment Organism Textmining
embryonic fibroblast
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 Mus musculus
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fibroblast embryonic fibriblast Mus musculus
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skeletal muscle expresses 50fold higher levels of FIH than other tissues Mus musculus
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Synonyms

Synonyms Comment Organism
asparaginyl hydroxylase
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 Mus musculus
FIH
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 Mus musculus
hypoxia-inducible factor 1-alpha inhibitor
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 Mus musculus

General Information

General Information Comment Organism
physiological function FIH loss increases oxidative metabolism and also increases glycolytic capacity, this gives rise to an increase in oxygen consumption. The loss of FIH acts to accelerate the cellular metabolic response to hypoxia. FIH suppresses hypoxia-induced mitochondrial reactive oxygen species production and FIH loss accelerates the effects of hypoxic exposure on mitochondria Mus musculus
physiological function the enzyme controls HIF transcriptional activity in an oxygen-dependent manner Mus musculus