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Literature summary for 1.14.11.33 extracted from

  • Silvestrov, P.; Mueller, T.A.; Clark, K.N.; Hausinger, R.P.; Cisneros, G.A.
    Homology modeling, molecular dynamics, and site-directed mutagenesis study of AlkB human homolog 1 (ALKBH1) (2014), J. Mol. Graph. Model., 54, 123-130 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli CodonPlus RIPL cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C118A the mutant shows wild type activity Homo sapiens
C118A/C129A the mutant shows wild type activity Homo sapiens
C129A the mutant shows wild type activity Homo sapiens
C129A/H134A the mutant shows 65% of wild type activity Homo sapiens
C304A the mutant shows wild type activity Homo sapiens
C304A/C371A the mutant shows wild type activity Homo sapiens
C371A the mutant shows wild type activity Homo sapiens
C371A/H372A the mutant shows wild type activity Homo sapiens
H113A the mutant shows wild type activity Homo sapiens
H113A/C118A the mutant shows 83% of wild type activity Homo sapiens
H113A/C118A/C129A/H134A the mutant shows 69% of wild type activity Homo sapiens
H113A/C129A the mutant shows wild type activity Homo sapiens
H134A the mutant shows wild type activity Homo sapiens
H303A the mutant shows wild type activity Homo sapiens
H303A/C304A the mutant shows wild type activity Homo sapiens
H372A the mutant shows wild type activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA-base-CH3 + 2-oxoglutarate + O2 Homo sapiens
-
DNA-base + formaldehyde + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA-base-CH3 + 2-oxoglutarate + O2
-
Homo sapiens DNA-base + formaldehyde + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
ABH1
-
Homo sapiens
AlkB homolog 1
-
Homo sapiens