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Literature summary for 1.14.11.38 extracted from

  • Steffan, N.; Grundmann, A.; Afiyatullov, S.; Ruan, H.; Li, S.M.
    FtmOx1, a non-heme Fe(II) and alpha-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus (2009), Org. Biomol. Chem., 7, 4082-4087.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ascorbate required Aspergillus fumigatus

Cloned(Commentary)

Cloned (Comment) Organism
-
Aspergillus fumigatus

Inhibitors

Inhibitors Comment Organism Structure
EDTA 1 mM Aspergillus fumigatus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required Aspergillus fumigatus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35100
-
2 * 35100, calculated from sequence Aspergillus fumigatus
38000
-
2 * 38000, SDS-PAGE Aspergillus fumigatus
81000
-
gel filtration Aspergillus fumigatus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2 Aspergillus fumigatus the enzyme is involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgin A verruculogen + succinate + CO2 + H2O + A
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus fumigatus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Aspergillus fumigatus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2 the enzyme is involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgin A Aspergillus fumigatus verruculogen + succinate + CO2 + H2O + A
-
?
fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2 fumitremorgin B i.e. (5aR,6S,12S,14aS)-5a,6-dihydroxy-9-methoxy-11-(3-methylbut-2-en-1-yl)-12-(2-methylprop-1-en-1-yl)-1,2,3,5a,6,11,12,14a-octahydro-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione. Both atoms of a dioxygen molecule are incorporated into verruculogen Aspergillus fumigatus verruculogen + succinate + CO2 + H2O + A verruculogen i.e. (5R,10S,10aR,14aS,15bS)-10,10a-dihydroxy-6-methoxy-2,2-dimethyl-5-(2-methylprop-1-en-1-yl)-1,10,10a,14,14a,15b-hexahydro-12H-3,4-dioxa-5a,11a,15a-triazacycloocta[1,2,3-lm]indeno[5,6-b]fluorene-11,15(2H,13H)-dione ?

Subunits

Subunits Comment Organism
homodimer 2 * 38000, SDS-PAGE Aspergillus fumigatus
homodimer 2 * 35100, calculated from sequence Aspergillus fumigatus

Synonyms

Synonyms Comment Organism
fmtF
-
Aspergillus fumigatus
FmtOx1
-
Aspergillus fumigatus