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Literature summary for 1.14.11.39 extracted from

  • Neary, J.M.; Powell, A.; Gordon, L.; Milne, C.; Flett, F.; Wilkinson, B.; Smith, C.P.; Micklefield, J.
    An asparagine oxygenase (AsnO) and a 3-hydroxyasparaginyl phosphotransferase (HasP) are involved in the biosynthesis of calcium-dependent lipopeptide antibiotics (2007), Microbiology, 153, 768-776.
    View publication on PubMed
Search for more literature for 1.14.11.39

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-asparagine + 2-oxoglutarate + O2 Streptomyces coelicolor
-
 (2S,3S)-3-hydroxyasparagine + succinate + CO2
-
 ?
L-asparagine + 2-oxoglutarate + O2 Streptomyces coelicolor A3(2)
-
 (2S,3S)-3-hydroxyasparagine + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces coelicolor Q9Z4Z5
-
-
Streptomyces coelicolor A3(2) Q9Z4Z5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-asparagine + 2-oxoglutarate + O2
-
 Streptomyces coelicolor (2S,3S)-3-hydroxyasparagine + succinate + CO2
-
 ?
L-asparagine + 2-oxoglutarate + O2
-
 Streptomyces coelicolor A3(2) (2S,3S)-3-hydroxyasparagine + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
AsnO
-
 Streptomyces coelicolor
asparagine oxygenase
-
 Streptomyces coelicolor
SCO3236
-
 Streptomyces coelicolor

General Information

General Information Comment Organism
malfunction deletion mutants produce several new Asn-containing calcium-dependent antibiotics not present in the wild type, which retain calcium-dependent antimicrobial activity Streptomyces coelicolor
physiological function the enzyme is required for the beta-hydroxylation of the Asn residue within calcium-dependent antibiotic Streptomyces coelicolor