Reference to 1.14.11.4; Id = 439149 - BRENDA Enzyme Database

inactivation by freezing/thawing

Gallus gallus

inactivation by freezing/thawing

Homo sapiens

labile in tissue extracts

Gallus gallus

labile in tissue extracts

Homo sapiens

loss of activity during concentration

Gallus gallus

loss of activity during concentration

Homo sapiens

stabilization by detergents, NaCl

Gallus gallus

stabilization by detergents, NaCl

Homo sapiens

0.4

0.5

Procollagen L-lysine

-

Gallus gallus

0.4

0.5

Procollagen L-lysine

-

Homo sapiens

endoplasmic reticulum

-

Gallus gallus

5783

-

endoplasmic reticulum

-

Homo sapiens

5783

-

Fe2+

-

Gallus gallus

Fe2+

-

Homo sapiens

200000

-

Gallus gallus

-

Homo sapiens

-

glycoprotein

-

Gallus gallus

glycoprotein

-

Homo sapiens

-

Gallus gallus

embryo

-

Gallus gallus

-

embryo

-

Homo sapiens

-

placenta

-

Homo sapiens

-

additional information

-

assay methods

Gallus gallus

additional information

-

assay methods

Homo sapiens

-20Â°C

Gallus gallus

-20Â°C

Homo sapiens

peptidyl-L-lysine + 2-oxoglutarate + O2

minimum sequence required: Xaa-Lys-Gly

439149

Gallus gallus

peptidyl-5-hydroxy-L-lysine + succinate + CO2

-

?

peptidyl-L-lysine + 2-oxoglutarate + O2

minimum sequence required: Xaa-Lys-Gly

439149

Homo sapiens

peptidyl-5-hydroxy-L-lysine + succinate + CO2

-

?

[procollagen] L-lysine + 2-oxoglutarate + O2

-

439149

Gallus gallus

[procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2

-

r

[procollagen] L-lysine + 2-oxoglutarate + O2

-

439149

Homo sapiens

[procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2

-

r

dimer

-

Gallus gallus

additional information

-

additional information

-

Gallus gallus

additional information

-

additional information

-

Homo sapiens

7.4

-

Gallus gallus

7.4

-

Homo sapiens

ascorbate

-

Gallus gallus

ascorbate

-

Homo sapiens

ascorbate

-

Gallus gallus

ascorbate

-

Homo sapiens

inactivation by freezing/thawing

Gallus gallus

inactivation by freezing/thawing

Homo sapiens

labile in tissue extracts

Gallus gallus

labile in tissue extracts

Homo sapiens

loss of activity during concentration

Gallus gallus

loss of activity during concentration

Homo sapiens

stabilization by detergents, NaCl

Gallus gallus

stabilization by detergents, NaCl

Homo sapiens

0.4

0.5

Procollagen L-lysine

-

Gallus gallus

0.4

0.5

Procollagen L-lysine

-

Homo sapiens

endoplasmic reticulum

-

Gallus gallus

5783

-

endoplasmic reticulum

-

Homo sapiens

5783

-

Fe2+

-

Gallus gallus

Fe2+

-

Homo sapiens

200000

-

Gallus gallus

glycoprotein

-

Gallus gallus

glycoprotein

-

Homo sapiens

-

Gallus gallus

embryo

-

Gallus gallus

-

embryo

-

Homo sapiens

-

placenta

-

Homo sapiens

-

additional information

-

assay methods

Gallus gallus

additional information

-

assay methods

Homo sapiens

-20Â°C

Gallus gallus

-20Â°C

Homo sapiens

peptidyl-L-lysine + 2-oxoglutarate + O2

minimum sequence required: Xaa-Lys-Gly

439149

Gallus gallus

peptidyl-5-hydroxy-L-lysine + succinate + CO2

-

?

peptidyl-L-lysine + 2-oxoglutarate + O2

minimum sequence required: Xaa-Lys-Gly

439149

Homo sapiens

peptidyl-5-hydroxy-L-lysine + succinate + CO2

-

?

[procollagen] L-lysine + 2-oxoglutarate + O2

-

439149

Gallus gallus

[procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2

-

r

[procollagen] L-lysine + 2-oxoglutarate + O2

-

439149

Homo sapiens

[procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2

-

r

dimer

-

Gallus gallus

additional information

-

additional information

-

Gallus gallus

additional information

-

additional information

-

Homo sapiens

7.4

-

Gallus gallus

7.4

-

Homo sapiens

744168

Guo

A scalable lysyl hydroxylase ...

Homo sapiens

Arch. Biochem. Biophys.

618

45-51

2017

1

-

1

-

2

-

2

3

-

1

-

1

-

3

-

1

-

3

-

3

1

-

2

1

-

1

-

1

-

2

-

2

-

3

-

1

-

1

-

1

-

3

-

1

-

2

1

-

2

-

2

746479

Chen

FKBP65-dependent peptidyl-pro ...

Mus musculus

Sci. Rep.

7

46021

2017

1

-

1

-

2

-

2

-

3

-

2

-

3

-

1

-

1

-

2

-

3

-

2

-

1

-

746556

Neyazi

Procollagen-lysine, 2-oxoglut ...

Homo sapiens

World Neurosurg.

102

79-84

2017

-

1

-

1

-

3

-

3

-

1

-

4

-

1

-

1

-

3

-

1

-

1

-

746171

Heard

Sc65-null mice provide eviden ...

Mus musculus, Mus musculus 714

PLoS Genet.

12

e1006002

2016

-

1

-

2

-

1

-

2

-

6

-

4

-

2

-

3

-

1

-

2

-

1

-

2

-

4

-

2

-

3

-

745323

Dayer

Recruitment of matrix metallo ...

Homo sapiens

J. Biol. Chem.

290

13763-13778

2015

-

1

-

4

-

1

-

1

-

1

-

1

-

3

-

1

-

4

-

1

-

1

-

1

-

2

-

745334

Gjaltema

Procollagen lysyl hydroxylase ...

Homo sapiens

J. Biol. Chem.

290

28465-28476

2015

-

1

-

1

-

1

-

2

-

1

-

5

-

1

-

1

-

2

-

1

-

1

-

745431

Kogan

Cannabidiol, a major non-psyc ...

Rattus norvegicus

J. Bone Miner. Res.

30

1905-1913

2015

3

-

3

-

3

-

8

-

8

-

3

-

6

-

3

-

3

-

3

-

8

-

3

-

3

-

745445

Chen

Lysyl hydroxylase 2 induces a ...

Homo sapiens, Mus musculus

J. Clin. Invest.

125

1147-1162

2015

-

1

2

-

2

-

2

-

6

-

9

-

2

-

8

-

1

2

-

2

-

2

-

9

-

2

-

3

-

745769

Zhang

Essential roles of insulin, A ...

Mus musculus

Mol. Cell. Endocrinol.

399

164-177

2015

-

3

-

1

-

2

-

3

-

3

-

9

-

3

-

11

-

3

-

1

-

6

-

3

-

9

-

3

-

9

-

746253

Risteli

Lysyl hydroxylase 3 modifies ...

Mus musculus, Mus musculus C57BL/6

PLoS ONE

9

e113498

2014

-

1

-

6

-

9

-

8

-

2

-

1

-

6

-

8

-

2

-

724702

Remst

TGF-beta induces lysyl hydroxy ...

Homo sapiens

Cell Tissue Res.

355

163-171

2013

-

1

-

1

-

8

-

5

-

1

-

3

-

1

-

1

-

5

-

1

-

1

2

1

-

724792

Tsukamoto

Cloning and expression of cDNA ...

Takifugu rubripes

Comp. Biochem. Physiol. B

166

123-132

2013

-

3

-

3

-

3

-

6

-

3

-

44

-

3

6

-

3

-

3

-

3

-

3

-

3

-

44

-

3

-

3

-

3

-

725955

Gilkes

Procollagen lysyl hydroxylase ...

Homo sapiens

Mol. Cancer Res.

11

456-466

2013

-

1

-

1

-

3

-

5

-

2

-

1

-

1

-

1

-

5

-

2

-

1

2

1

-

722865

Wang

Lysyl hydroxylase 3 is secrete ...

Canis lupus familiaris, Homo sapiens, Canis lupus familiaris Madin-Darby

J. Cell. Physiol.

227

668-675

2012

-

1

-

1

-

6

-

3

-

5

-

4

-

6

-

4

-

1

-

1

-

6

-

3

-

4

-

6

-

1

2

1

-

725865

Mantri

-

Self-hydroxylation of the spli ...

Homo sapiens

MedChemComm

3

80-85

2012

-

1

-

2

-

1

-

4

-

3

-

1

-

2

-

4

-

1

-

726309

Ruotsalainen

The activities of lysyl hydrox ...

Mus musculus, Mus musculus C57BL/6

PLoS ONE

7

e50045

2012

-

2

-

146

-

1

-

2

-

2

-

1

-

2

-

725092

Bunt

Characterisation of the Drosop ...

Drosophila melanogaster

Gene Expr. Patterns

11

72-78

2011

-

1

-

1

-

1

-

10

-

3

-

2

-

2

-

1

-

1

-

1

-

3

-

2

-

2

-

725453

Luther

Mimivirus collagen is modified ...

Acanthamoeba polyphaga Mimivirus, Acanthamoeba polyphaga Mimivirus L230

J. Biol. Chem.

286

43701-43709

2011

-

1

-

5

-

1

-

4

-

22

-

1

-

8

-

1

-

1

-

1

-

5

-

1

-

4

-

1

-

8

-

1

-

1

-

1

-

725464

Sricholpech

Lysyl hydroxylase 3 glucosylat ...

Mus musculus, Mus musculus CRL-2593

J. Biol. Chem.

286

8846-8856

2011

-

1

-

1

-

2

-

4

-

1

-

2

-

2

-

2

-

1

-

1

-

2

-

1

-

2

-

2

-

2

-

725860

Heikkinen

Dimerization of human lysyl hy ...

Homo sapiens

Matrix Biol.

30

27-33

2011

-

12

-

2

-

6

-

3

1

2

-

12

-

2

-

3

1

-

1

-

712761

Mantri

Crystal structure of the 2-oxo ...

Homo sapiens

J. Mol. Biol.

401

211-222

2010

2

-

1

-

2

1

-

5

-

1

-

2

1

-

1

-

2

-

1

-

1

-

2

1

-

1

-

2

1

-

1

-

696584

Stein

Production of bioactive, post- ...

Homo sapiens

Biomacromolecules

10

2640-2645

2009

-

1

-

1

-

9

-

1

-

2

-

1

-

1

-

1

-

698942

Risteli

Reduction of lysyl hydroxylase ...

Homo sapiens

J. Biol. Chem.

284

28204-28211

2009

-

1

-

6

-

4

-

1

-

6

-

4

-

3

-

2

-

1

-

6

-

4

-

1

-

4

-

3

-

4

-

698949

Hyry

Missense mutations that cause ...

Homo sapiens

J. Biol. Chem.

284

30917-30924

2009

1

-

1

-

3

-

5

-

1

-

1

-

3

-

1

-

2

-

1

-

1

-

1

-

3

-

5

-

1

-

1

-

1

-

2

-

1

-

699120

Wang

The glycosyltransferase activi ...

Homo sapiens

J. Cell. Mol. Med.

13

508-521

2009

-

1

-

3

-

1

-

1

-

2

-

1

-

8

-

2

-

1

-

3

-

1

-

1

-

1

-

8

-

699401

Yeowell

TIA nuclear proteins regulate ...

Homo sapiens

J. Invest. Dermatol.

129

1402-1411

2009

-

1

-

1

-

7

-

1

-

1

-

1

-

2

1

2

-

701230

Webby

Jmjd6 catalyses lysyl-hydroxyl ...

Homo sapiens

Science

325

90-93

2009

-

1

-

2

1

-

2

-

3

-

1

-

3

-

1

-

1

-

2

1

-

2

-

1

-

3

-

695440

Salo

A connective tissue disorder c ...

Homo sapiens

Am. J. Hum. Genet.

83

495-503

2008

-

3

-

1

-

6

-

3

-

1

-

5

-

3

-

1

-

3

-

1

-

3

-

696018

Nagaoka

1,25(OH)2D3 regulates collagen ...

Mus musculus

Biochem. Biophys. Res. Commun.

377

674-678

2008

-

1

-

2

-

1

-

2

-

2

-

1

-

1

-

2

-

2

-

2

-

1

-

1

-

675767

Schneider

Genomic structure and embryoni ...

Danio rerio

Matrix Biol.

26

12-19

2007

-

13

-

3

-

3

-

6

-

3

-

3

-

675768

Takaluoma

Lysyl hydroxylase 2 is a speci ...

Homo sapiens

Matrix Biol.

26

396-403

2007

-

1

-

9

-

4

-

1

-

5

-

4

-

1

-

9

-

1

-

5

-

687672

Takaluoma

Tissue-specific changes in the ...

Mus musculus

J. Biol. Chem.

282

6588-6596

2007

-

1

-

8

-

1

-

673470

Wu

Functional diversity of lysyl ...

Homo sapiens

Exp. Cell Res.

312

3485-3494

2006

-

6

-

3

-

1

-

2

-

3

-

1

-

675017

Ruotsalainen

Glycosylation catalyzed by lys ...

Mus musculus

J. Cell Sci.

119

625-635

2006

-

5

-

5

-

1

-

2

-

5

-

1

-

675031

Salo

Lysyl hydroxylase 3 (LH3) modi ...

Mus musculus

J. Cell. Physiol.

207

644-653

2006

-

2

-

1

-

3

-

9

-

2

-

2

-

2

-

1

-

9

-

2

-

675766

Salo

The lysyl hydroxylase isoforms ...

Mus musculus

Matrix Biol.

25

475-483

2006

-

2

-

2

-

4

-

9

-

4

-

2

-

2

-

9

-

659652

Walker

A novel mutation in the lysyl ...

Homo sapiens

J. Invest. Dermatol.

124

914-918

2005

-

1

-

1

-

2

-

4

-

2

-

2

-

2

-

1

-

1

-

2

-

2

-

2

-

659845

Walker

Tissue-specific expression and ...

Homo sapiens

Matrix Biol.

23

515-523

2005

-

1

-

2

-

6

-

16

-

3

-

2

-

1

-

2

-

16

-

3

-

674991

Pornprasertsuk

Overexpression of lysyl hydrox ...

Mus musculus

J. Bone Miner. Res.

20

81-87

2005

-

1

-

5

-

2

-

1

-

2

-

1

-

1

-

1

-

2

-

1

-

675763

Zuurmond

Minoxidil exerts different inh ...

Homo sapiens

Matrix Biol.

24

261-270

2005

-

1

-

1

-

3

-

4

-

1

-

3

-

659379

Risteli

Characterization of collagenou ...

Caenorhabditis elegans, Homo sapiens

J. Biol. Chem.

279

37535-37543

2004

-

1

-

1

-

1

-

2

-

12

-

1

-

5

-

4

-

1

-

1

-

1

-

1

-

2

-

1

-

5

-

659548

Pornprasertsuk

Lysyl hydroxylase-2b directs c ...

Mus musculus

J. Bone Miner. Res.

19

1349-1355

2004

-

1

-

1

-

1

-

3

1

-

2

-

2

-

1

-

1

-

3

1

-

2

-

657744

Mercer

Identification, expression, an ...

Rattus norvegicus

Biochem. Biophys. Res. Commun.

307

803-809

2003

-

2

-

2

-

6

-

18

1

-

5

-

8

-

2

-

2

-

18

1

-

5

-

657816

Suokas

Retrieval-independent localiza ...

Homo sapiens

Biochem. J.

370

913-920

2003

-

1

-

2

-

3

1

-

1

-

1

-

2

-

2

-

1

-

2

-

3

1

-

1

-

2

-

659266

van der Slot

Identification of PLOD2 as tel ...

Homo sapiens

J. Biol. Chem.

278

40967-40972

2003

-

1

-

1

-

1

-

4

-

2

-

2

-

4

-

1

-

1

-

1

-

2

-

2

-

439166

Rautavuoma

Characterization of three frag ...

Homo sapiens

J. Biol. Chem.

277

23084-23091

2002

-

1

-

5

-

1

2

-

6

-

1

-

1

-

5

1

-

1

-

5

-

1

2

-

1

-

1

-

5

1

-

439167

Wang

Identification of amino acids ...

Caenorhabditis elegans

J. Biol. Chem.

277

18568-18573

2002

-

1

-

2

-

10

-

1

-

1

-

1

-

2

-

1

-

1

-

439168

Samimi

Mechanism of inhibition of lys ...

Rattus norvegicus

Toxicol. Appl. Pharmacol.

176

181-186

2001

-

1

-

2

-

1

2

-

1

-

1

-

3

1

-

2

-

1

-

2

-

1

2

-

1

-

3

1

-

439165

Passoja

Cloning and characterization o ...

Homo sapiens

Proc. Natl. Acad. Sci. USA

95

10482-10486

1998

-

1

2

-

7

-

1

-

9

-

1

-

1

-

5

1

-

1

2

-

7

-

1

-

1

-

1

-

5

1

-

439164

Valtavaara

Cloning and characterization o ...

Homo sapiens

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272

6831-6834

1997

-

2

-

1

2

-

4

-

2

-

5

-

3

1

-

1

-

2

1

-

1

2

-

2

-

5

-

3

1

-

439169

Armstrong

Rat lysyl hydroxylase: molecul ...

Gallus gallus, Homo sapiens, Rattus norvegicus

Biochim. Biophys. Acta

1264

93-102

1995

-

2

1

-

3

-

1

-

14

-

2

-

3

-

5

1

-

2

1

-

3

-

1

-

2

-

3

-

5

1

-

439163

Kellokumpu

Lysyl hydroxylase, a collagen ...

Homo sapiens

J. Biol. Chem.

269

30524-30529

1994

-

2

-

1

-

1

-

2

-

1

-

2

-

1

-

2

-

1

-

349014

Majamaa

Differences between collagen h ...

Gallus gallus

Biochem. J.

229

127-133

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-

3

-

1

-

1

-

3

-

1

-

439151

Royce

Failure of highly purified lys ...

Gallus gallus

Biochem. J.

230

475-480

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-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

439149

Kivirikko

Posttranslational enzymes in t ...

Gallus gallus, Homo sapiens

Methods Enzymol.

82

245-304

1982

-

8

-

2

1

-

2

-

2

1

-

3

2

4

1

-

2

-

2

-

2

-

8

-

2

1

-

2

1

-

3

2

4

1

-

2

-

439150

Puistola

Catalytic properties of lysyl ...

Gallus gallus, Homo sapiens

Biochem. J.

201

215-219

1982

-

2

-

2

-

5

-

7

-

2

-

2

-

2

-

2

-

2

-

7

-

2

-

439148

Kivirikko

-

The hydroxylation of prolyl an ...

Gallus gallus

Enzymol. Post- transl. Modif. Proteins (Freedman, R. B. , Hawkins, H. C. , eds. ) Academic Press, New York

1

53-104

1980

-

1

-

1

-

1

-

1

-

1

-

3

1

-

1

-

1

-

1

-

1

-

1

-

3

1

-

439152

Puistola

Studies on the lysyl hydroxyla ...

Gallus gallus

Biochim. Biophys. Acta

611

40-50

1980

4

-

5

-

1

-

1

-

1

-

3

-

1

-

4

-

1

-

5

-

1

-

1

-

3

-

439153

Puistola

Studies on the lysyl hydroxyla ...

Gallus gallus

Biochim. Biophys. Acta

611

51-60

1980

-

8

-

1

-

1

-

1

-

8

-

1

-

439154

Turpeenniemi-Hujanen

Isolation of lysyl hydroxylase ...

Gallus gallus

Biochem. J.

189

247-253

1980

-

1

-

1

-

1

-

1

-

1

2

1

-

1

-

1

-

1

-

1

-

1

2

1

-

1

-

439155

Miller

-

Purification and enzymatic pro ...

Sus scrofa

Biochemistry

18

5928-5932

1979

3

-

3

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

3

-

3

-

2

-

1

-

1

-

1

-

1

-

439156

Murray

Inhibition of lysyl hydroxylas ...

Gallus gallus

Biochim. Biophys. Acta

481

63-70

1977

-

11

-

1

-

1

-

6

-

1

-

1

-

1

-

1

-

11

1

-

1

-

1

-

1

-

1

-

1

-

439157

Ryhänen

Lysyl hydroxylase. Further pur ...

Gallus gallus

Biochim. Biophys. Acta

438

71-89

1976

3

-

5

-

2

-

1

-

1

-

1

-

3

-

5

-

2

-

1

-

1

-

439158

Kivirikko

Studies on protocollagen lysin ...

Gallus gallus

Biochemistry

11

122-129

1972

-

3

-

1

-

1

-

1

-

4

-

3

-

1

-

1

-

4

-

439159

Popenoe

Partial purification and prope ...

Gallus gallus

Biochim. Biophys. Acta

258

380-386

1972

2

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

439160

Kivirikko

Partial purification and chara ...

Gallus gallus

Biochim. Biophys. Acta

258

366-379

1972

3

-

1

-

1

2

-

1

-

1

-

1

3

-

1

-

1

-

3

-

1

-

1

-

1

-

1

-

1

2

-

1

-

1

3

-

1

-

439162

Hausmann E.

Cofactor requirements for the ...

Gallus gallus

Biochim. Biophys. Acta

133

591-593

1967

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes

Data extracted from this reference: