Literature summary for 1.14.11.4 extracted from

  • van der Slot, A.J.; Zuurmond, A.M.; Bardoel, A.F.; Wijmenga, C.; Pruijs, H.E.; Sillence, D.O.; Brinckmann, J.; Abraham, D.J.; Black, C.M.; Verzijl, N.; DeGroot, J.; Hanemaaijer, R.; TeKoppele, J.M.; Huizinga, T.W.; Bank, R.A.
    Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis (2003), J. Biol. Chem., 278, 40967-40972.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene PLOD2, DNA and amino acid sequence determination and analysis Homo sapiens

Engineering

Protein Variants Comment Organism
additional information identification of a PLOD2 mutant bearing 2 missense mutations in exon 17 in patients with Buck syndrome caused by a pyrolidine deficiency in bone due to decreased enzyme activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
procollagen L-lysine + 2-oxoglutarate + O2 Homo sapiens enzyme is important in fibrosis because its hydroxylation activity of lysine residues in telopeptides leads to increased cross-linking of accumulated collagen with pyrolidine in fibrotic tissues, enzyme expression in increased in systemic sclerosis procollagen 5-hydroxy-L-lysine + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O00469 isozyme LH2, gene PLOD2; gene PLOD2 encoding isozyme LH2
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast from fibrotic skin of patients with systemic sclerosis Homo sapiens
-
skin fibrotic skin from patients with systemic sclerosis Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
procollagen L-lysine + 2-oxoglutarate + O2
-
Homo sapiens procollagen 5-hydroxy-L-lysine + succinate + CO2
-
?
procollagen L-lysine + 2-oxoglutarate + O2 enzyme is important in fibrosis because its hydroxylation activity of lysine residues in telopeptides leads to increased cross-linking of accumulated collagen with pyrolidine in fibrotic tissues, enzyme expression in increased in systemic sclerosis Homo sapiens procollagen 5-hydroxy-L-lysine + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
lysyl hydroxylase
-
Homo sapiens
telopeptide lysyl hydroxylase
-
Homo sapiens
TLH
-
Homo sapiens
LH2
-
Homo sapiens