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Literature summary for 1.14.11.4 extracted from
- Lysyl hydroxylase 2 is a specific telopeptide hydroxylase, while all three isoenzymes hydroxylate collagenous sequences (2007), Matrix Biol., 26, 396-403.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in H5 insect cells | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.04 | - |
type IV procollagen | isozyme LH2, at 37°C | Homo sapiens | |
| 0.05 | - |
type IV procollagen | isozyme LH3, at 37°C | Homo sapiens | |
| 0.08 | - |
type I procollagen | isozyme LH3, at 37°C | Homo sapiens | |
| 0.1 | - |
type I procollagen | isozyme LH2, at 37°C | Homo sapiens | |
| 0.23 | - |
type I procollagen | isozyme LH1, at 37°C | Homo sapiens | |
| 0.3 | - |
type IV procollagen | isozyme LH1, at 37°C | Homo sapiens | |
| 0.31 | - |
(Ile-Lys-Gly)3 | isozyme LH2, at 37°C | Homo sapiens |  |
| 0.34 | - |
(Ile-Lys-Gly)3 | isozyme LH3, at 37°C | Homo sapiens | |
| 0.47 | - |
(Ile-Lys-Gly)3 | isozyme LH1, at 37°C | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| ProBond metal chelate affinity resin chromatography and Chelating Sepharose fast flow column chromatography | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (Ile-Lys-Gly)3 + 2-oxoglutarate + O2 | - |
Homo sapiens | ? | - |
? | |
| collagen + 2-oxoglutarate + O2 | - |
Homo sapiens | 5-hydroxylysyl-collagen + succinate + CO2 | - |
? | |
| additional information | LH2 hydroxylates the N telopeptide of the full-length procollagen alpha type I chain when coexpressed with this isoenzyme | Homo sapiens | ? | - |
? | |
| type I procollagen + 2-oxoglutarate + O2 | - |
Homo sapiens | ? | - |
? | |
| type IV procollagen + 2-oxoglutarate + O2 | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LH1 | - |
Homo sapiens |
| LH2 | - |
Homo sapiens |
| LH3 | - |
Homo sapiens |
| lysyl hydroxylase | - |
Homo sapiens |
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