Literature summary for 1.14.11.4 extracted from

Takaluoma, K.; Hyry, M.; Lantto, J.; Sormunen, R.; Bank, R.A.; Kivirikko, K.I.; Myllyharju, J.; Soininen, R.
Tissue-specific changes in the hydroxylysine content and cross-links of collagens and alterations in fibril morphology in lysyl hydroxylase 1 knock-out mice (2007), J. Biol. Chem., 282, 6588-6596.

Search for more literature for 1.14.11.4

Protein Variants

Protein Variants	Comment	Organism
additional information	mice with targeted inactivation of the Plod1 gene for lysyl hydroyxylase 1 are flaccid and have gait abnormalities. About 15% of them die because of aortic rupture, and smooth muscle cells in non-ruptured Plod1-/- aortas show degenerative changes. Collagen fibrils in the Plod1-/- aorta and skin have an abnormal morphology. The lysyl hydrolase activity level in the Plod1-/- skin and aorta samples is 35-45% of that in the wild type. The hydroxylysine content is decreased in all the Plod1-/- tissues, ranging from 22% of that in the wild type in the skin to 75% and 86% in the femur and lung, respectively	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9R0E2	isoform lysyl hydroxylase 1	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)