Cloned (Comment) | Organism |
---|---|
endogenous LH2 alternate splicing pattern and conservation analysis of LH2 genomic sequence., overview. Construction and expression of a functional LH2 minigene in HEK-293 cells, human neonatal skin fibroblasts, and mouse embryonic fibroblasts. The TIA proteins play a role in the regulation of the alternative splicing of LH2, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | siRNA knockdowns of TIA-1 and TIAL1 both singly and in combination in HEK293 cells decrease the ratio of LH2 (long) to LH2 (short) splicing variants | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme LH2 | - |
Synonyms | Comment | Organism |
---|---|---|
lysyl hydroxylase 2 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | reduction of TIA protein levels in mous embryonic fibroblasts and HEK-293 cells leads to a corresponding decrease in the LH2(long) spliced product in both the minigene and the endogenous gene | down |
Homo sapiens | overexpression of the TIA proteins in HEK-293 cells leads to an increase in levels of the LH2(long) spliced product in the minigene | up |
General Information | Comment | Organism |
---|---|---|
malfunction | although differential expression of LH2 (long) is associated with fibrotic conditions, there is no direct evidence that the increased Pyr cross-links in the overaccumulated collagen contribute definitively to fibrosis | Homo sapiens |