Application | Comment | Organism |
---|---|---|
medicine | LH2b is an interesting target to interfere with osteoarthritis-related persistent fibrosis | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene PLOD2, encoding for splice variants LH2a and LH2b, quantitative expression analysis of LH2b | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysine-[procollagen] + 2-oxoglutarate + O2 | Homo sapiens | - |
(2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene PLOD2, encoding for splice variants LH2a and LH2b | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | synovial osteoarthritic | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysine-[procollagen] + 2-oxoglutarate + O2 | - |
Homo sapiens | (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
2-oxoglutarate 5-dioxygenase 2 | - |
Homo sapiens |
LH2b | - |
Homo sapiens |
lysyl hydroxylase 2b | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | in osteoarthritic human synovial fibroblasts, the enzyme expression is induced by TGF-beta via kinase ALK5, not ALK1, and Smad2/3P | up |
General Information | Comment | Organism |
---|---|---|
metabolism | in osteoarthritic human synovial fibroblasts, the enzyme expression is induced by TGF-beta via kinase ALK5, not ALK1, and Smad2/3P | Homo sapiens |
physiological function | lysyl hydroxylases are enzymes that catalyze the hydroxylation of lysine into hydroxylysine and, therefore, fulfill a crucial role in collagen modification and cross-linking. Lysyl hydroxylase 2b increases pyridinoline cross-links, making collagen less susceptible to enzymatic degradation | Homo sapiens |