Literature summary for 1.14.11.4 extracted from

  • Bunt, S.; Denholm, B.; Skaer, H.
    Characterisation of the Drosophila procollagen lysyl hydroxylase, dPlod (2011), Gene Expr. Patterns, 11, 72-78.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene dPlod or CG6199, maps to cytological position 68B1 on the left arm of the third chromosome, DNA and amino acid sequence determination and analysis, sequence comparisons Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
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Drosophila melanogaster
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine-[procollagen] + 2-oxoglutarate + O2 Drosophila melanogaster collagen type IV (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2
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?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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gene dPlod, or CG6199, encoding the only lysyl hydroxylase of the organism
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Source Tissue

Source Tissue Comment Organism Textmining
additional information developmental expression patterns of dPlod RNA and protein during embryogenesis,overview. dPlod is highly expressed in type-IV collagen-producing cells, particularly the hemocytes and fat body Drosophila melanogaster
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fat body
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Drosophila melanogaster
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hemocyte
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Drosophila melanogaster
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine-[procollagen] + 2-oxoglutarate + O2
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Drosophila melanogaster (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2
-
?
L-lysine-[procollagen] + 2-oxoglutarate + O2 collagen type IV Drosophila melanogaster (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
lysyl hydroxylase
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Drosophila melanogaster
LH3
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Drosophila melanogaster

General Information

General Information Comment Organism
physiological function dPlod is required for type-IV collagen secretion from hemocytes and fat body Drosophila melanogaster
evolution LH3 belongs to the lysyl hydroxylase family of enzymes that has important roles in the biosynthesis of collagen Drosophila melanogaster