Literature summary for 1.14.11.4 extracted from

  • Heikkinen, J.; Risteli, M.; Lampela, O.; Alavesa, P.; Karppinen, M.; Juffer, A.; Myllylae, R.
    Dimerization of human lysyl hydroxylase 3 (LH3) is mediated by the amino acids 541-547 (2011), Matrix Biol., 30, 27-33.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information monomerization inactivates the LH activity of LH3, distribution of monomers, dimers, and multimers in mutant enzyme structures, overview. Glycosyltransferase activity of the mutant enzymes, overview Homo sapiens
E542A site-directed mutagenesis Homo sapiens
E547A site-directed mutagenesis Homo sapiens
E542A/E547A site-directed mutagenesis Homo sapiens
E542A/H546L/E547A site-directed mutagenesis Homo sapiens
K541M site-directed mutagenesis Homo sapiens
Q543L/Y544F site-directed mutagenesis Homo sapiens
E542A/E547A/E574A/E579A site-directed mutagenesis Homo sapiens
E542A/E547A/E574A/E579A/E560A site-directed mutagenesis Homo sapiens
E542A/Q543L/Y544F/E547A/E574A site-directed mutagenesis Homo sapiens
E579A/E560A site-directed mutagenesis Homo sapiens
K541M/E542A site-directed mutagenesis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens lysyl hydroxylase 3 is a multifunctional enzyme of collagen biosynthesis, with glycosyltransferase activity and lysyl hydroxylase activity ?
-
?
L-lysine-[procollagen] + 2-oxoglutarate + O2 Homo sapiens
-
(2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information lysyl hydroxylase 3 is a multifunctional enzyme of collagen biosynthesis, with glycosyltransferase activity and lysyl hydroxylase activity Homo sapiens ?
-
?
L-lysine-[procollagen] + 2-oxoglutarate + O2
-
Homo sapiens (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2
-
?
L-lysine-[procollagen] + 2-oxoglutarate + O2 the hydroxylysyl residues are located in Y positions of X-Y-Gly repeats of collagenous sequences Homo sapiens (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO2
-
?

Subunits

Subunits Comment Organism
dimer localization of the region responsible for the dimerization of lysyl hydroxylase 3, to a sequence of amino acids between the glycosyltransferase activity and the lysyl hydroxylase activity domains. This area is covered by amino acids 541-547 and contains no cysteine residues Homo sapiens

Synonyms

Synonyms Comment Organism
lysyl hydroxylase 3
-
Homo sapiens
LH3
-
Homo sapiens

General Information

General Information Comment Organism
additional information heterocomplex formation between mouse and human LH3, between human LH1 and LH3 and between human LH2 and LH3, low amount of complexes formed in vivo Homo sapiens