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Literature summary for 1.14.11.51 extracted from

  • Wu, T.P.; Wang, T.; Seetin, M.G.; Lai, Y.; Zhu, S.; Lin, K.; Liu, Y.; Byrum, S.D.; Mackintosh, S.G.; Zhong, M.; Tackett, A.; Wang, G.; Hon, L.S.; Fang, G.; Swenberg, J.A.; Xiao, A.Z.
    DNA methylation on N-adenine in mammalian embryonic stem cells (2016), Nature, 532, 329-333.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
D233A reduced activity of the recombinant mutant protein Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ contains Fe2+ Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43746
-
x * 43746, calculated from sequence Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N6-methyladenine in DNA + 2-oxoglutarate + O2 Mus musculus the enzyme catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons adenine in DNA + formaldehyde + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P0CB42
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N6-methyladenine in DNA + 2-oxoglutarate + O2
-
Mus musculus adenine in DNA + formaldehyde + succinate + CO2
-
?
N6-methyladenine in DNA + 2-oxoglutarate + O2 the enzyme catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons Mus musculus adenine in DNA + formaldehyde + succinate + CO2
-
?

Subunits

Subunits Comment Organism
? x * 43746, calculated from sequence Mus musculus

Synonyms

Synonyms Comment Organism
ALKBH1
-
Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme catalyses oxidative demethylation of DNA N6-methyladenine, a prevalent modification in LINE-1 transposons Mus musculus