Application | Comment | Organism |
---|---|---|
medicine | expression levels of ALKBH1 in lung cancer tissues and cells are up regulated. The invasion and migration abilities of lung cancer cells are significantly suppressed in vitro upon the silencing of ALKBH1 while they are significantly promoted upon its overexpression | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
structure to 3.1 A resolution. The N-terminal domain of the protein forms close contacts with the core catalytic domain and might be responsible for the recognition of nucleic acid substrates. H231, D233 and H287 are ligands of the catalytic iron metal | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
D233A | residue plays an important role in substrate recognition and catalysis | Homo sapiens |
H231A | residue plays an important role in substrate recognition and catalysis | Homo sapiens |
H287A | residue plays an important role in substrate recognition and catalysis | Homo sapiens |
R338A | residue plays an important role in substrate recognition and catalysis | Homo sapiens |
R344A | mutation in highly conserved residue, strong decrease in demethylation ability | Homo sapiens |
Y184A | mutation in highly conserved residue, strong decrease in demethylation ability | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Iron | H231, D233 and H287 are ligands of the catalytic iron metal | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13686 | bifunctional apurinic/apyrimidinic sites lyase and m6A demethylase, cf. EC 4.2.99.18 | - |
Mus musculus | P0CB42 | bifunctional apurinic/apyrimidinic sites lyase and m6A demethylase, cf. EC 4.2.99.18 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
BEAS-2B cell | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
NCI-H1299 cell | - |
Homo sapiens | - |
NCI-H1650 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ALKBH1 | - |
Mus musculus |
ALKBH1 | - |
Homo sapiens |