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Literature summary for 1.14.11.51 extracted from

  • Li, H.; Zhang, Y.; Guo, Y.; Liu, R.; Yu, Q.; Gong, L.; Liu, Z.; Xie, W.; Wang, C.
    ALKBH1 promotes lung cancer by regulating m6A RNA demethylation (2021), Biochem. Pharmacol., 189, 114284 .
    View publication on PubMed

Application

Application Comment Organism
medicine expression levels of ALKBH1 in lung cancer tissues and cells are up regulated. The invasion and migration abilities of lung cancer cells are significantly suppressed in vitro upon the silencing of ALKBH1 while they are significantly promoted upon its overexpression Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
structure to 3.1 A resolution. The N-terminal domain of the protein forms close contacts with the core catalytic domain and might be responsible for the recognition of nucleic acid substrates. H231, D233 and H287 are ligands of the catalytic iron metal Mus musculus

Protein Variants

Protein Variants Comment Organism
D233A residue plays an important role in substrate recognition and catalysis Homo sapiens
H231A residue plays an important role in substrate recognition and catalysis Homo sapiens
H287A residue plays an important role in substrate recognition and catalysis Homo sapiens
R338A residue plays an important role in substrate recognition and catalysis Homo sapiens
R344A mutation in highly conserved residue, strong decrease in demethylation ability Homo sapiens
Y184A mutation in highly conserved residue, strong decrease in demethylation ability Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Iron H231, D233 and H287 are ligands of the catalytic iron metal Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13686 bifunctional apurinic/apyrimidinic sites lyase and m6A demethylase, cf. EC 4.2.99.18
-
Mus musculus P0CB42 bifunctional apurinic/apyrimidinic sites lyase and m6A demethylase, cf. EC 4.2.99.18
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
BEAS-2B cell
-
Homo sapiens
-
lung
-
Homo sapiens
-
NCI-H1299 cell
-
Homo sapiens
-
NCI-H1650 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
ALKBH1
-
Mus musculus
ALKBH1
-
Homo sapiens